
38-Year-Old Female with Preeclampsia
Ms. Johansen, 38, is 26 weeks pregnant with her first child. She was diagnosed with preeclampsia (see p. 1114) three weeks ago. Antihypertensive drugs (p. 724) and daily home care monitoring were initiated. However, her blood pressure is continuing to rise and is now 162/108 mm Hg. She complains of a constant headache, exhibits edema, and her urinalysis is positive for protein.
Her doctor has her admitted and orders further blood tests to assess Ms. Johansen's platelet level and liver function. "We may have to deliver because that’s the only cure for preeclampsia." she says to you during your clinical rotation in obstetrics. “But if we do, then the baby will have problems. It’s a tough decision because we have to balance both the mother's and the baby’s health.”
5. NCLEX-STYLE Cortisol prompts the fetal lungs to begin synthesizing surfactant. Why is this important?
a. Surfactant reduces surface tension in the alveoli, allowing the alveoli to inflate.
b. Surfactant causes vasodilation, allowing blood to flow through the lungs.
c. Surfactant is necessary to protect the cells lining the respiratory tract from drying out.
d. Surfactant attracts white blood cells into the lungs to protect them against pathogens.

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Chapter 28 Solutions
EBK HUMAN ANAT.+PHYSIOLOGY
- The following figure is from Caterina et al. The capsaicin receptor: a heat activated ion channel in the pain pathway. Nature, 1997. Black boxes indicate capsaicin, white circles indicate resinferatoxin. You are a chef in a fancy new science-themed restaurant. You have a recipe that calls for 1 teaspoon of resinferatoxin, but you feel uncomfortable serving foods with "toxins" in them. How much capsaicin could you substitute instead?arrow_forwardWhat protein is necessary for packaging acetylcholine into synaptic vesicles?arrow_forward1. Match each vocabulary term to its best descriptor A. affinity B. efficacy C. inert D. mimic E. how drugs move through body F. how drugs bind Kd Bmax Agonist Antagonist Pharmacokinetics Pharmacodynamicsarrow_forward
- 50 mg dose of a drug is given orally to a patient. The bioavailability of the drug is 0.2. What is the volume of distribution of the drug if the plasma concentration is 1 mg/L? Be sure to provide units.arrow_forwardDetermine Kd and Bmax from the following Scatchard plot. Make sure to include units.arrow_forwardChoose a catecholamine neurotransmitter and describe/draw the components of the synapse important for its signaling including synthesis, packaging into vesicles, receptors, transporters/degradative enzymes. Describe 2 drugs that can act on this system.arrow_forward
- The following figure is from Caterina et al. The capsaicin receptor: a heat activated ion channel in the pain pathway. Nature, 1997. Black boxes indicate capsaicin, white circles indicate resinferatoxin. a) Which has a higher potency? b) Which is has a higher efficacy? c) What is the approximate Kd of capsaicin in uM? (you can round to the nearest power of 10)arrow_forwardWhat is the rate-limiting-step for serotonin synthesis?arrow_forwardWhat enzyme is necessary for synthesis of all of the monoamines?arrow_forward
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