BIOCHEMISTRY (LOOSELEAF)-W/ACCESS
9th Edition
ISBN: 9781319425784
Author: BERG
Publisher: Macmillan Higher Education
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Question
Chapter 28, Problem 2P
Interpretation Introduction
Interpretation:
Among the given compounds, the compound which satisfies all of Lipinski’s rules should be identified.
Concept introduction:
Lipinski’s rule also known as Pfizer’s rule of five. It is a thumb rule to determine that a chemical compound with biological or pharmacological activity will likely be an orally active drug or not.
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9. Which one of the compounds below is the major organic product obtained from
the following reaction sequence, starting with ethyl acetoacetate?
요요.
1. NaOCH2CH3
CH3CH2OH
1. NaOH, H₂O
2. H3O+
3. A
OCH2CH3
2.
ethyl acetoacetate
ii
A
3. H3O+
OH
B
C
D
E
7. Only one of the following ketones cannot be made via an acetoacetic ester
synthesis. Which one is it?
Ph
کہ
A
B
C
D
E
2. Which one is the
major organic
product obtained
from the following
reaction sequence?
HO
A
OH
1. NaOEt, EtOH
1. LiAlH4
EtO
OEt
2. H3O+
2. H3O+
OH
B
OH
OH
C
-OH
HO
-OH
OH
D
E
.CO₂Et
Chapter 28 Solutions
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