Human Anatomy & Physiology, Books a la Carte Edition (2nd Edition)
2nd Edition
ISBN: 9780134754239
Author: Erin C. Amerman
Publisher: PEARSON
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Chapter 27.5, Problem 3QC
Which hormone stimulates the beginning of childbirth, and where does this hormone originate?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 27 Solutions
Human Anatomy & Physiology, Books a la Carte Edition (2nd Edition)
Ch. 27.1 - What are the three major periods of prenatal...Ch. 27.1 - 2. When does the postnatal period of life begin?
Ch. 27.2 - Prob. 1QCCh. 27.2 - What are the steps of fertilization?Ch. 27.2 - 3. What is the function of cleavage of the...Ch. 27.2 - How does a morula differ from a blastocyst?Ch. 27.2 - 5. What is the ultimate fate of the inner cell...Ch. 27.2 - 6. Which cell type secretes hCG?
Ch. 27.2 - 7. What are the functions of amniotic fluid?
Ch. 27.2 - 8. What are the main functions of each of the...
Ch. 27.3 - Prob. 1QCCh. 27.3 - 2. Which cells form the three germ layers?
Ch. 27.3 - 3. What are the two types of embryonic folding?...Ch. 27.3 - What is the first major event that occurs during...Ch. 27.3 - Prob. 5QCCh. 27.4 - Prob. 1QCCh. 27.4 - Prob. 2QCCh. 27.4 - What specific changes occur in each month of fetal...Ch. 27.4 - Prob. 4QCCh. 27.5 - Prob. 1QCCh. 27.5 - Prob. 2QCCh. 27.5 - Which hormone stimulates the beginning of...Ch. 27.5 - Prob. 4QCCh. 27.6 - What are the criteria used to determine a newborns...Ch. 27.6 - Prob. 2QCCh. 27.6 - 3. Explain what happens to each structure in the...Ch. 27.6 - Prob. 4QCCh. 27.6 - What role do hormones play in the let-down reflex...Ch. 27.7 - What is the genome? How many chromosomes are in...Ch. 27.7 - Prob. 2QCCh. 27.7 - 3. How does a genotype differ from a phenotype?
Ch. 27.7 - Prob. 4QCCh. 27.7 - Prob. 5QCCh. 27.7 - 6. What is an X-linked disorder? How can a female...Ch. 27 - Match the correct time period of gestation with...Ch. 27 - Prob. 2CYRCh. 27 - Mark the following statements about fertilization...Ch. 27 - Prob. 4CYRCh. 27 - Number the sequence of events in fertilization....Ch. 27 - Prob. 6CYRCh. 27 - Match the extraembryonic membrane with the correct...Ch. 27 - Prob. 8CYRCh. 27 - Match the structures of the embryo with the...Ch. 27 - What are the two types of embryonic folding?Ch. 27 - Prob. 11CYRCh. 27 - Prob. 12CYRCh. 27 - Prob. 13CYRCh. 27 - Prob. 14CYRCh. 27 - Prob. 15CYRCh. 27 - Prob. 16CYRCh. 27 - 17. Fill in the blanks: The first ____________...Ch. 27 - Prob. 18CYRCh. 27 - Prob. 19CYRCh. 27 - Which pattern of inheritance includes examples of...Ch. 27 - Prob. 1CYUCh. 27 - Why is the single-celled zygote approximately the...Ch. 27 - Prob. 3CYUCh. 27 - Prob. 4CYUCh. 27 - Prob. 1AYKACh. 27 - Prob. 2AYKACh. 27 - Prob. 3AYKACh. 27 - Prob. 4AYKACh. 27 - Prob. 5AYKB
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- Select a diet and give a summary of the main components. Do a web search of the diet and choose one link that provides misinformation. Explain why the site itself and/or the information on the site is not credible. This should be a report. This site should be different from U.S News and World Report. For full credit, you must include the following information and elaborate in detail: The diet name The main components of the diet The misinformation website and link What misinformation is being provided in the other website and how did you determine it was not credible?arrow_forward1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.arrow_forward2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…arrow_forward
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