Campbell Biology in Focus; Modified Mastering Biology with Pearson eText -- ValuePack Access Card -- for Campbell Biology in Focus (2nd Edition)
2nd Edition
ISBN: 9780134433776
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman
Publisher: PEARSON
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Chapter 27.5, Problem 2CC
MAKE CONNECTIONS Compare and contrast how the colonization of land by plants and by vertebrates exemplifies descent with modification. (Review Concepts 19.2 and 26.1.)
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 27 Solutions
Campbell Biology in Focus; Modified Mastering Biology with Pearson eText -- ValuePack Access Card -- for Campbell Biology in Focus (2nd Edition)
Ch. 27.1 - Prob. 1CCCh. 27.1 - Prob. 2CCCh. 27.2 - What is the Cambrian explosion? Why is it...Ch. 27.2 - Prob. 2CCCh. 27.3 - Prob. 1CCCh. 27.3 - WHAT IF? Would it be accurate to describe the...Ch. 27.4 - Prob. 1CCCh. 27.4 - Describe two key adaptations of aquatic...Ch. 27.4 - MAKE CONNECTIONS The radiation of bilaterians in...Ch. 27.5 - Describe two adaptations that have enabled insects...
Ch. 27.5 - MAKE CONNECTIONS Compare and contrast how the...Ch. 27.6 - Describe three key amniote adaptations for life on...Ch. 27.6 - Prob. 2CCCh. 27.6 - WHAT IF? Which came first, the chicken or the egg?...Ch. 27.7 - Describe how ocean communities changed in the...Ch. 27.7 - Prob. 2CCCh. 27.7 - Prob. 3CCCh. 27 - Prob. 1TYUCh. 27 - Fossil steroid and molecular clock evidence...Ch. 27 - Which of the following was probably the least...Ch. 27 - Prob. 4TYUCh. 27 - Prob. 5TYUCh. 27 - Prob. 6TYUCh. 27 - Prob. 7TYUCh. 27 - FOCUS ON EVOLUTION In Figure 27.29, circle the...Ch. 27 - FOCUS ON ORGANIZATION Early tetrapods had a...Ch. 27 - SYNTHESIZE YOUR KNOWLEDGE Collectively, do these...
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