Brock Biology of Microorganisms (15th Edition)
15th Edition
ISBN: 9780134261928
Author: Michael T. Madigan, Kelly S. Bender, Daniel H. Buckley, W. Matthew Sattley, David A. Stahl
Publisher: PEARSON
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Chapter 27.5, Problem 1MQ
Identify the cells that display MHC class I and MHC class II proteins on their surfaces.
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Identify the cells that display MHC class I and MHC class IIproteins on their surfaces
Describe five important differences between class I and class II MHC proteins
List the steps of MHC class II peptide formation and assembly.
Chapter 27 Solutions
Brock Biology of Microorganisms (15th Edition)
Ch. 27.1 - Prob. 1MQCh. 27.1 - Prob. 2MQCh. 27.1 - Distinguish between clonal deletion and clonal...Ch. 27.1 - QWhy is it necessary that all three defining...Ch. 27.2 - Identify the intrinsic and extrinsic properties of...Ch. 27.2 - Describe an epitope recognized by an antibody, and...Ch. 27.2 - Give an example for each: natural and artificial...Ch. 27.2 - QWhat properties are required for a vaccine to...Ch. 27.3 - Summarize antibody production starting with...Ch. 27.3 - Differentiate among antibody classes using...
Ch. 27.3 - Prob. 3MQCh. 27.3 - QDescribe the structural and functional...Ch. 27.4 - Draw a complete Ig molecule and identify...Ch. 27.4 - Describe antigen binding to the CDR1, 2, and 3...Ch. 27.4 - Describe the recombination events that produce a...Ch. 27.4 - QWhich Ig chains are used to construct a complete...Ch. 27.5 - Identify the cells that display MHC class I and...Ch. 27.5 - Compare the MHC I and MHC II protein structures...Ch. 27.5 - Define the sequence of events for processing and...Ch. 27.5 - QDescribe the basic structure of class I and class...Ch. 27.6 - Define polymorphism and polygeny as they apply to...Ch. 27.6 - How does a single MHC protein present many...Ch. 27.6 - QPolymorphism implies that each different MHC...Ch. 27.7 - Prob. 1MQCh. 27.7 - Identify diversity-generating mechanisms unique to...Ch. 27.7 - Describe and compare the structural features of Ig...Ch. 27.7 - QWhat diversity-generating mechanisms function to...Ch. 27.8 - Describe the mechanism used by Tc cells to...Ch. 27.8 - Describe the effector system (the cell-killing...Ch. 27.8 - Compare and contrast the roles and activities of...Ch. 27.8 - QWhat mechanism do Tc cells use to identify and...Ch. 27.9 - Discriminate between immediate hypersensitivity...Ch. 27.9 - Provide examples and mechanisms for an...Ch. 27.9 - QHow do immediate and delayed-type...Ch. 27.10 - Describe the binding site for superantigens on T...Ch. 27.10 - Compare and contrast the immunodeficiency observed...Ch. 27.10 - Prob. 3MQCh. 27.10 - Prob. 1CRCh. 27 - Antibodies of the IgA class are probably more...Ch. 27 - Prob. 2AQCh. 27 - Polymorphism implies that each different MHC...Ch. 27 - What problems would arise if a person had a...
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- Write T if the statement is correct; write F if the statement is not correct. Antigen fragments that bind to MHC class I molecules are typically in endosomes. " " TAP1 and TAP2 are present on the plasma membrane of APCs. " " Proteasomes process antigens within the endoplasmic reticulum. " " Newly synthesized MHC class I molecules can be found within endosomes. " " Newly synthesized MHC class I α chains assemble in the ER with calnexin. " "arrow_forwardWhere are Class I MHC proteins and Class II MHC proteins found?correct answerarrow_forwardWhat is MHC? List the specific cells that have MHC presentation and describe their role in the immune response.arrow_forward
- Distinguish between class I and class II MHC proteins.arrow_forwardCompare the MHC I and MHC II protein structures and peptidebinding sites. How do they differ? How are they similar?arrow_forwardWhat types of cells display MHC class I and class IIantigen complexes, and what happens as a result?arrow_forward
- Major histocompatibility proteins (MHC) presented with an antigen: are recognized by T lymphocytes both may be expressed by any nucleated cell and are recognized by T lymphocytes both may be expressed by any nucleated cell and are recognized by B lymphocytes may be expressed by any nucleated cell are recognized by B lymphocytesarrow_forwardWhich type of MHC-class molecule is found on all nucleated cells and is used to communicate with cytotoxic T-lymphocytes? Which classes are displayed on APCs, and which class is used specifically to communicate with (a) helper T-lymphocytes and (b) cytotoxic T-lymphocytes?arrow_forwardPeptides are stably bound to MHC molecules, and also serve to stabilize the MHC molecule on the cell surface. Once expressed on the surface of host cells, an MHC protein remains stably associated with its bound peptide for several days. This highly stable peptide binding behavior is important because: a) It prevents peptide exchanges on the cell surface, ensuring that peptide:MHC complexes are reliable indicators of the proteins present inside that host cell. b) If the MHC protein lost its peptide it would become unstable, and would be rapidly internalized and degraded. c) Pathogens would otherwise evade the immune response by making decoy peptides that mimic host cell peptides. d) Pathogens would be able to evade the T cell response by making proteases that cleave MHC proteins inducing peptide release. e) Immune responses to infection often induce noxious chemicals that damage surface MHC proteins, and might result in peptide loss.arrow_forward
- Empty MHC class I and MHC class II molecules are rapidly removed from the cell surface. This process prevents: The accumulation of empty MHC molecules on the cell surface which would interfere with T cells recognizing pathogen-derived peptide:MHC complexes Pathogens from evading the immune response by inducing peptide release from cell surface MHC molecules MHC class I molecules from being internalized into endosomes and binding endosome-derived peptides HLA-DM from trafficking to the cell surface with MHC class II Inappropriate T cell recognition of healthy cells that are not infected, nor have ingested a pathogenarrow_forwardClass II MHC proteins display what kind of antigens? What class of T cell recognizes antigens bound to class II MHC? What types of cells display these proteins?arrow_forwardWhat is a membrane histocompatibility complex? Contrast MHC I and MHC II.arrow_forward
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