CONNECT FOR ANATOMY AND PHYSIOLOGY >IC
11th Edition
ISBN: 9781260018462
Author: VanPutte
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Textbook Question
Chapter 27.4, Problem 26AYP
Describe the effects of hypocalcemia and hypercalcemia on membrane potentials.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 27 Solutions
CONNECT FOR ANATOMY AND PHYSIOLOGY >IC
Ch. 27.1 - What are the two major fluid compartments of the...Ch. 27.1 - Prob. 2AYPCh. 27.1 - Prob. 3AYPCh. 27.1 - What factors contribute to edema?Ch. 27.2 - Prob. 5AYPCh. 27.2 - Prob. 6AYPCh. 27.2 - Prob. 7AYPCh. 27.2 - Prob. 8AYPCh. 27.2 - Prob. 9AYPCh. 27.2 - Prob. 10AYP
Ch. 27.2 - Prob. 11AYPCh. 27.2 - What effect does atrial natriuretic hormone (ANH)...Ch. 27.2 - Prob. 13AYPCh. 27.3 - Prob. 14AYPCh. 27.3 - What characteristic of the plasma membrane is...Ch. 27.4 - Prob. 16AYPCh. 27.4 - Prob. 17AYPCh. 27.4 - Prob. 18AYPCh. 27.4 - Prob. 19AYPCh. 27.4 - Prob. 20AYPCh. 27.4 - Prob. 21AYPCh. 27.4 - Prob. 22AYPCh. 27.4 - What effect does an increase or a decrease in...Ch. 27.4 - Prob. 24AYPCh. 27.4 - Prob. 25AYPCh. 27.4 - Describe the effects of hypocalcemia and...Ch. 27.4 - Prob. 27AYPCh. 27.4 - Prob. 28AYPCh. 27.4 - Prob. 29AYPCh. 27.4 - Prob. 30AYPCh. 27.4 - Prob. 31AYPCh. 27.4 - Prob. 32AYPCh. 27.4 - Prob. 33AYPCh. 27.4 - Prob. 34AYPCh. 27.4 - Prob. 35AYPCh. 27.5 - Prob. 36AYPCh. 27.5 - Prob. 37AYPCh. 27.5 - What ore the three major mechanismsthat regulate...Ch. 27.5 - Compare the capacity and rate at which the...Ch. 27.5 - Prob. 40AYPCh. 27.5 - Name the three buffer systems of the body. Which...Ch. 27.5 - Prob. 42AYPCh. 27.5 - Prob. 43AYPCh. 27.5 - Prob. 44AYPCh. 27.5 - Prob. 45AYPCh. 27.5 - Prob. 46AYPCh. 27.5 - Prob. 47AYPCh. 27.5 - What is alkalosis? What are the two types, and...Ch. 27 - Prob. 1RACCh. 27 - Prob. 2RACCh. 27 - Prob. 3RACCh. 27 - Prob. 4RACCh. 27 - Prob. 5RACCh. 27 - Prob. 6RACCh. 27 - A decrease in extracellular K+ a. produces...Ch. 27 - Calcium ion concentration in the blood decreases...Ch. 27 - Prob. 9RACCh. 27 - Prob. 10RACCh. 27 - Prob. 11RACCh. 27 - Prob. 12RACCh. 27 - Prob. 13RACCh. 27 - Prob. 14RACCh. 27 - Prob. 15RACCh. 27 - Prob. 16RACCh. 27 - Prob. 1CTCh. 27 - A patient suffering from a tumor in the...Ch. 27 - Acetazolamide is a diuretic that blocksthe...Ch. 27 - As part of a physiology experiment, an anatomy and...Ch. 27 - Prob. 5CT
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