The genetic basis of acquired resistance to β-lactam antibiotics in Staphylococcus aureus . Design the laboratory experiments to reverse resistance to the β-lactam antibiotics. Can this experiment be applied “in the field” to promote deselection of antibiotic-resistant organisms? Introduction: The β-lactam antibiotics are the inhibitors of the synthesis of the bacterial cell wall. The mechanism and synthesis of the cell wall are unique in bacteria. The β-lactam antibiotics are the highly selective antibiotics and they target only on the bacterial cell wall and do not produce any toxic effect on the host. The β-lactam antibiotics, including penicillins and cephalosporins, are found to be the cell wall synthesis inhibitors. These antibiotics have a β-lactam ring in their structures.

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Chapter 27, Problem 4AQ

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The genetic basis of acquired resistance to β-lactam antibiotics in Staphylococcus aureus. Design the laboratory experiments to reverse resistance to the β-lactam antibiotics. Can this experiment be applied “in the field” to promote deselection of antibiotic-resistant organisms?

Introduction:

The β-lactam antibiotics are the inhibitors of the synthesis of the bacterial cell wall. The mechanism and synthesis of the cell wall are unique in bacteria. The β-lactam antibiotics are the highly selective antibiotics and they target only on the bacterial cell wall and do not produce any toxic effect on the host. The β-lactam antibiotics, including penicillins and cephalosporins, are found to be the cell wall synthesis inhibitors. These antibiotics have a β-lactam ring in their structures.

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