Chapter 27, Problem 3CT

Acetazolamide is a diuretic that blocksthe activity of the enzyme carbonic anhydrase inside kidney tubule cells. This blockage prevents the formation of carbonic acid from ${\text{CO}}_2$ and water. Normally, carbonicacid dissociates to form ${\text{H}}^{\text{+}}$ and ${\text{HCO}}_3^{-}$ , and the ${\text{H}}^{\text{+}}$ is exchanged for ${\text{Na}}^{\text{+}}$ from the urine. Blocking the formation of ${\text{H}}^{\text{+}}$ in the tubule cellsblocks ${\text{Na}}^{\text{+}}$ reabsorption, thus Inhibiting water reabsorption and producing the diuretic effect With this information in mind, what effect does acetazolamide have on bloodpH,urine pH, and respiratory rate?