(a) Interpretation: The given amino acid is to be prepared using acetoamidomalonate method. Concept Introduction: The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion form reacts with alkyl halide . Then, hydrolysis of intermediate compound takes place which results in product formation. Answer: The synthesis of given amino acid using acetoamidomalonate method is shown below. Explanation: The given isobutylene reacts with DBr/H 2 O to form bromoisobutane. Diethylacetamidomalonate forms enolate ion in the presence of sodium ethoxide and ethanol. Then enolate ion is alkylated with bromoisobutane. The compound formed is treated with hot aqueous hydrogen bromide. First, the ester hydrolysis takes place. Second, the decarboxylation of carboxylic group takes place. Third, acetamido group and amide gets hydrolysed. This results in the product formation. The complete reaction is shown below. Figure 1 Conclusion: The complete synthesis of given compound is shown in Figure 1.

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Answer 1

Question

Chapter 27, Problem 27.72AP

Interpretation Introduction

(a)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion form reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

Answer:

The synthesis of given amino acid using acetoamidomalonate method is shown below.

Explanation:

The given isobutylene reacts with DBr/H₂O to form bromoisobutane. Diethylacetamidomalonate forms enolate ion in the presence of sodium ethoxide and ethanol. Then enolate ion is alkylated with bromoisobutane. The compound formed is treated with hot aqueous hydrogen bromide. First, the ester hydrolysis takes place. Second, the decarboxylation of carboxylic group takes place. Third, acetamido group and amide gets hydrolysed. This results in the product formation. The complete reaction is shown below.

Figure 1

Conclusion:

The complete synthesis of given compound is shown in Figure 1.

Interpretation Introduction

(b)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion forms reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

Interpretation Introduction

(c)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion forms reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

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Technetium is the first element in the periodic chart that does not have any stable isotopes. Technetium-99m is an especially interesting and valuable isotope as it emits a gamma ray with a half life ideally suited for medical tests. It would seem that the decay of technetium should fit the treatment above with the result In(c/c) = -kt. The table below includes data from the two sites: http://dailymed.nlm.nih.gov/dailymed/druginfo.cfm?id=7130 http://wiki.medpedia.com/Clinical: Neutrospec_(Technetium_(99m Tc)_fanolesomab). a. b. C. Graph the fraction (c/c.) on the vertical axis versus the time on the horizontal axis. Also graph In(c/c.) on the vertical axis versus time on the horizontal axis. When half of the original amount of starting material has hours fraction remaining disappeared, c/c = ½ and the equation In(c/c.) = -kt becomes In(0.5) = -kt1/2 where t₁₂ is the half life (the time for half of the material to decay away). Determine the slope of your In(c/c.) vs t graph and…

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1. a) Assuming that an atom of arsenic has hydrogen-like atomic orbitals, sketch the radial probability plots for 4p and 4d orbitals of S atom. Indicate angular and radial nodes in these orbitals. (4 points) b) Calculate Zeff experienced by and electron in 4p AO's in a arsenic atom. Use Slater rules that were discussed in lecture. (3 points)

Answer 2

Question

Chapter 27, Problem 27.72AP

Interpretation Introduction

(a)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion form reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

Answer:

The synthesis of given amino acid using acetoamidomalonate method is shown below.

Explanation:

The given isobutylene reacts with DBr/H₂O to form bromoisobutane. Diethylacetamidomalonate forms enolate ion in the presence of sodium ethoxide and ethanol. Then enolate ion is alkylated with bromoisobutane. The compound formed is treated with hot aqueous hydrogen bromide. First, the ester hydrolysis takes place. Second, the decarboxylation of carboxylic group takes place. Third, acetamido group and amide gets hydrolysed. This results in the product formation. The complete reaction is shown below.

Figure 1

Conclusion:

The complete synthesis of given compound is shown in Figure 1.

Interpretation Introduction

(b)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion forms reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

Interpretation Introduction

(c)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion forms reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

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Answer 3

Question

Chapter 27, Problem 27.72AP

Interpretation Introduction

(a)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion form reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

Answer:

The synthesis of given amino acid using acetoamidomalonate method is shown below.

Explanation:

The given isobutylene reacts with DBr/H₂O to form bromoisobutane. Diethylacetamidomalonate forms enolate ion in the presence of sodium ethoxide and ethanol. Then enolate ion is alkylated with bromoisobutane. The compound formed is treated with hot aqueous hydrogen bromide. First, the ester hydrolysis takes place. Second, the decarboxylation of carboxylic group takes place. Third, acetamido group and amide gets hydrolysed. This results in the product formation. The complete reaction is shown below.

Figure 1

Conclusion:

The complete synthesis of given compound is shown in Figure 1.

Interpretation Introduction

(b)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion forms reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

Interpretation Introduction

(c)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion forms reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

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Answer 4

Question

Chapter 27, Problem 27.72AP

Interpretation Introduction

(a)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion form reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

Answer:

The synthesis of given amino acid using acetoamidomalonate method is shown below.

Explanation:

The given isobutylene reacts with DBr/H₂O to form bromoisobutane. Diethylacetamidomalonate forms enolate ion in the presence of sodium ethoxide and ethanol. Then enolate ion is alkylated with bromoisobutane. The compound formed is treated with hot aqueous hydrogen bromide. First, the ester hydrolysis takes place. Second, the decarboxylation of carboxylic group takes place. Third, acetamido group and amide gets hydrolysed. This results in the product formation. The complete reaction is shown below.

Figure 1

Conclusion:

The complete synthesis of given compound is shown in Figure 1.

Interpretation Introduction

(b)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion forms reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

Interpretation Introduction

(c)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion forms reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

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Answer 5

Chapter 27, Problem 27.72AP

Interpretation Introduction

(a)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion form reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

Answer:

The synthesis of given amino acid using acetoamidomalonate method is shown below.

Explanation:

The given isobutylene reacts with DBr/H₂O to form bromoisobutane. Diethylacetamidomalonate forms enolate ion in the presence of sodium ethoxide and ethanol. Then enolate ion is alkylated with bromoisobutane. The compound formed is treated with hot aqueous hydrogen bromide. First, the ester hydrolysis takes place. Second, the decarboxylation of carboxylic group takes place. Third, acetamido group and amide gets hydrolysed. This results in the product formation. The complete reaction is shown below.

Figure 1

Conclusion:

The complete synthesis of given compound is shown in Figure 1.

Interpretation Introduction

(b)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion forms reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

Interpretation Introduction

(c)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion forms reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

Answer 6

Chapter 27, Problem 27.72AP

Interpretation Introduction

(a)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion form reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

Answer:

The synthesis of given amino acid using acetoamidomalonate method is shown below.

Explanation:

The given isobutylene reacts with DBr/H₂O to form bromoisobutane. Diethylacetamidomalonate forms enolate ion in the presence of sodium ethoxide and ethanol. Then enolate ion is alkylated with bromoisobutane. The compound formed is treated with hot aqueous hydrogen bromide. First, the ester hydrolysis takes place. Second, the decarboxylation of carboxylic group takes place. Third, acetamido group and amide gets hydrolysed. This results in the product formation. The complete reaction is shown below.

Figure 1

Conclusion:

The complete synthesis of given compound is shown in Figure 1.

Answer 7

Chapter 27, Problem 27.72AP

Interpretation Introduction

(a)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion form reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

Answer:

The synthesis of given amino acid using acetoamidomalonate method is shown below.

Explanation:

The given isobutylene reacts with DBr/H₂O to form bromoisobutane. Diethylacetamidomalonate forms enolate ion in the presence of sodium ethoxide and ethanol. Then enolate ion is alkylated with bromoisobutane. The compound formed is treated with hot aqueous hydrogen bromide. First, the ester hydrolysis takes place. Second, the decarboxylation of carboxylic group takes place. Third, acetamido group and amide gets hydrolysed. This results in the product formation. The complete reaction is shown below.

Figure 1

Conclusion:

The complete synthesis of given compound is shown in Figure 1.

Answer 8

Interpretation Introduction

(b)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion forms reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

Answer 9

Interpretation Introduction

(b)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion forms reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

Answer 10

Interpretation Introduction

(c)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion forms reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

Answer 11

Interpretation Introduction

(c)

Interpretation:

The given amino acid is to be prepared using acetoamidomalonate method.

Concept Introduction:

The method used for preparation of α- amino acid is acetoamidomalonate method. In this reaction, diethylacetamidomalonate reacts with sodium ethoxide and ethanol to form enolate ion. The enolate ion forms reacts with alkyl halide. Then, hydrolysis of intermediate compound takes place which results in product formation.

Answer 12

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Answer 15

Ch. 27 - Prob. 27.1P Ch. 27 - Prob. 27.2P Ch. 27 - Prob. 27.3P Ch. 27 - Prob. 27.4P Ch. 27 - Prob. 27.5P Ch. 27 - Prob. 27.6P Ch. 27 - Prob. 27.8P Ch. 27 - Prob. 27.9P Ch. 27 - Prob. 27.10P Ch. 27 - Prob. 27.11P

Solution Summary: The author explains how the amino acid is prepared using acetoamidomalonate method.

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