(a) Interpretation: The effect of increasing the mass of stationaryphase relative to the packing masson the plate height needs to be explained. Concept introduction: As the number of plates increases in a GC column, the resolution would also increase. For increasing the number of plates, the height of the plates has to be decreased for maintaining a high resolution. The van Deemter equation is used for defining the effect of different parameters on the height of plate.

Question

1. Calculate the accurate monoisotopic mass (using all 1H, 12C, 14N, 160 and 35CI) for your product using the table in your lab manual. Don't include the Cl, since you should only have [M+H]*. Compare this to the value you see on the LC-MS printout. How much different are they? 2. There are four isotopic peaks for the [M+H]* ion at m/z 240, 241, 242 and 243. For one point of extra credit, explain what each of these is and why they are present. 3. There is a fragment ion at m/z 184. For one point of extra credit, identify this fragment and confirm by calculating the accurate monoisotopic mass. 4. The UV spectrum is also at the bottom of your printout. For one point of extra credit, look up the UV spectrum of bupropion on Google Images and compare to your spectrum. Do they match? Cite your source. 5. For most of you, there will be a second chromatographic peak whose m/z is 74 (to a round number). For one point of extra credit, see if you can identify this molecule as well and confirm by…

Answer 1

Question

Chapter 27, Problem 27.27QAP

Interpretation Introduction

(a)

Interpretation:

The effect of increasing the mass of stationaryphase relative to the packing masson the plate height needs to be explained.

Concept introduction:

As the number of plates increases in a GC column, the resolution would also increase. For increasing the number of plates, the height of the plates has to be decreased for maintaining a high resolution. The van Deemter equation is used for defining the effect of different parameters on the height of plate.

Interpretation Introduction

(b)

Interpretation:

The effect of decreasing the rate of sample injection on the plate height needs to be explained.

Concept introduction:

The resolution will increase as the number of plates increases in the GC column. For maintaining a high resolution and increasing the number of plates, the height of the plates must be decreased. For defining the effect of different parameters on the height of plate, van Deemter equation is used.

Interpretation Introduction

(c)

Interpretation:

The effect of increasing the injection port temperature on the plate height needs to be explained.

Concept introduction:

In GC column resolution will increases as the number of plates increases.For maintaining a high resolution and increasing the number of plates, the height of the plates has to be decreased. For defining the dependencies of various parameters on the height of plate, van Deemter equation is used.

Interpretation Introduction

(d)

Interpretation:

The effect of increasing the flow rate on the plate height needs to be explained.

Concept introduction:

As the number of plates increases in a GC column, the resolution would also increase. For increasing the number of plates, the height of the plates has to be decreased for maintaining a high resolution. The van Deemter equation is used for defining the effect of different parameters on the height of plate.

Interpretation Introduction

(e)

Interpretation:

The effect of reducing the particle sizeof the packing on the plate height needs to be explained.

Concept introduction:

The resolution will increase as the number of plates increases in the GC column. For maintaining a high resolution and increasing the number of plates, the height of the plates must be decreased. For defining the effect of different parameters on the height of plate, van Deemter equation is used.

Interpretation Introduction

(f)

Interpretation:

The effect of decreasing the column temperature on the plate height needs to be explained.

Concept introduction:

In GC column resolution will increases as the number of plates increases. For maintaining a high resolution and increasing the number of plates, the height of the plates has to be decreased. For defining the dependencies of various parameters on the height of plate, van Deemter equation is used.

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1. Calculate the accurate monoisotopic mass (using all 1H, 12C, 14N, 160 and 35CI) for your product using the table in your lab manual. Don't include the Cl, since you should only have [M+H]*. Compare this to the value you see on the LC-MS printout. How much different are they? 2. There are four isotopic peaks for the [M+H]* ion at m/z 240, 241, 242 and 243. For one point of extra credit, explain what each of these is and why they are present. 3. There is a fragment ion at m/z 184. For one point of extra credit, identify this fragment and confirm by calculating the accurate monoisotopic mass. 4. The UV spectrum is also at the bottom of your printout. For one point of extra credit, look up the UV spectrum of bupropion on Google Images and compare to your spectrum. Do they match? Cite your source. 5. For most of you, there will be a second chromatographic peak whose m/z is 74 (to a round number). For one point of extra credit, see if you can identify this molecule as well and confirm by…

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can you draw each step on a piece of a paper please this is very confusing to me

Answer 2

Question

Chapter 27, Problem 27.27QAP

Interpretation Introduction

(a)

Interpretation:

The effect of increasing the mass of stationaryphase relative to the packing masson the plate height needs to be explained.

Concept introduction:

As the number of plates increases in a GC column, the resolution would also increase. For increasing the number of plates, the height of the plates has to be decreased for maintaining a high resolution. The van Deemter equation is used for defining the effect of different parameters on the height of plate.

Interpretation Introduction

(b)

Interpretation:

The effect of decreasing the rate of sample injection on the plate height needs to be explained.

Concept introduction:

The resolution will increase as the number of plates increases in the GC column. For maintaining a high resolution and increasing the number of plates, the height of the plates must be decreased. For defining the effect of different parameters on the height of plate, van Deemter equation is used.

Interpretation Introduction

(c)

Interpretation:

The effect of increasing the injection port temperature on the plate height needs to be explained.

Concept introduction:

In GC column resolution will increases as the number of plates increases.For maintaining a high resolution and increasing the number of plates, the height of the plates has to be decreased. For defining the dependencies of various parameters on the height of plate, van Deemter equation is used.

Interpretation Introduction

(d)

Interpretation:

The effect of increasing the flow rate on the plate height needs to be explained.

Concept introduction:

As the number of plates increases in a GC column, the resolution would also increase. For increasing the number of plates, the height of the plates has to be decreased for maintaining a high resolution. The van Deemter equation is used for defining the effect of different parameters on the height of plate.

Interpretation Introduction

(e)

Interpretation:

The effect of reducing the particle sizeof the packing on the plate height needs to be explained.

Concept introduction:

The resolution will increase as the number of plates increases in the GC column. For maintaining a high resolution and increasing the number of plates, the height of the plates must be decreased. For defining the effect of different parameters on the height of plate, van Deemter equation is used.

Interpretation Introduction

(f)

Interpretation:

The effect of decreasing the column temperature on the plate height needs to be explained.

Concept introduction:

In GC column resolution will increases as the number of plates increases. For maintaining a high resolution and increasing the number of plates, the height of the plates has to be decreased. For defining the dependencies of various parameters on the height of plate, van Deemter equation is used.

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Answer 3

Question

Chapter 27, Problem 27.27QAP

Interpretation Introduction

(a)

Interpretation:

The effect of increasing the mass of stationaryphase relative to the packing masson the plate height needs to be explained.

Concept introduction:

As the number of plates increases in a GC column, the resolution would also increase. For increasing the number of plates, the height of the plates has to be decreased for maintaining a high resolution. The van Deemter equation is used for defining the effect of different parameters on the height of plate.

Interpretation Introduction

(b)

Interpretation:

The effect of decreasing the rate of sample injection on the plate height needs to be explained.

Concept introduction:

The resolution will increase as the number of plates increases in the GC column. For maintaining a high resolution and increasing the number of plates, the height of the plates must be decreased. For defining the effect of different parameters on the height of plate, van Deemter equation is used.

Interpretation Introduction

(c)

Interpretation:

The effect of increasing the injection port temperature on the plate height needs to be explained.

Concept introduction:

In GC column resolution will increases as the number of plates increases.For maintaining a high resolution and increasing the number of plates, the height of the plates has to be decreased. For defining the dependencies of various parameters on the height of plate, van Deemter equation is used.

Interpretation Introduction

(d)

Interpretation:

The effect of increasing the flow rate on the plate height needs to be explained.

Concept introduction:

As the number of plates increases in a GC column, the resolution would also increase. For increasing the number of plates, the height of the plates has to be decreased for maintaining a high resolution. The van Deemter equation is used for defining the effect of different parameters on the height of plate.

Interpretation Introduction

(e)

Interpretation:

The effect of reducing the particle sizeof the packing on the plate height needs to be explained.

Concept introduction:

The resolution will increase as the number of plates increases in the GC column. For maintaining a high resolution and increasing the number of plates, the height of the plates must be decreased. For defining the effect of different parameters on the height of plate, van Deemter equation is used.

Interpretation Introduction

(f)

Interpretation:

The effect of decreasing the column temperature on the plate height needs to be explained.

Concept introduction:

In GC column resolution will increases as the number of plates increases. For maintaining a high resolution and increasing the number of plates, the height of the plates has to be decreased. For defining the dependencies of various parameters on the height of plate, van Deemter equation is used.

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Answer 4

Question

Chapter 27, Problem 27.27QAP

Interpretation Introduction

(a)

Interpretation:

The effect of increasing the mass of stationaryphase relative to the packing masson the plate height needs to be explained.

Concept introduction:

As the number of plates increases in a GC column, the resolution would also increase. For increasing the number of plates, the height of the plates has to be decreased for maintaining a high resolution. The van Deemter equation is used for defining the effect of different parameters on the height of plate.

Interpretation Introduction

(b)

Interpretation:

The effect of decreasing the rate of sample injection on the plate height needs to be explained.

Concept introduction:

The resolution will increase as the number of plates increases in the GC column. For maintaining a high resolution and increasing the number of plates, the height of the plates must be decreased. For defining the effect of different parameters on the height of plate, van Deemter equation is used.

Interpretation Introduction

(c)

Interpretation:

The effect of increasing the injection port temperature on the plate height needs to be explained.

Concept introduction:

In GC column resolution will increases as the number of plates increases.For maintaining a high resolution and increasing the number of plates, the height of the plates has to be decreased. For defining the dependencies of various parameters on the height of plate, van Deemter equation is used.

Interpretation Introduction

(d)

Interpretation:

The effect of increasing the flow rate on the plate height needs to be explained.

Concept introduction:

As the number of plates increases in a GC column, the resolution would also increase. For increasing the number of plates, the height of the plates has to be decreased for maintaining a high resolution. The van Deemter equation is used for defining the effect of different parameters on the height of plate.

Interpretation Introduction

(e)

Interpretation:

The effect of reducing the particle sizeof the packing on the plate height needs to be explained.

Concept introduction:

The resolution will increase as the number of plates increases in the GC column. For maintaining a high resolution and increasing the number of plates, the height of the plates must be decreased. For defining the effect of different parameters on the height of plate, van Deemter equation is used.

Interpretation Introduction

(f)

Interpretation:

The effect of decreasing the column temperature on the plate height needs to be explained.

Concept introduction:

In GC column resolution will increases as the number of plates increases. For maintaining a high resolution and increasing the number of plates, the height of the plates has to be decreased. For defining the dependencies of various parameters on the height of plate, van Deemter equation is used.

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Answer 5

Chapter 27, Problem 27.27QAP

Interpretation Introduction

(a)

Interpretation:

The effect of increasing the mass of stationaryphase relative to the packing masson the plate height needs to be explained.

Concept introduction:

As the number of plates increases in a GC column, the resolution would also increase. For increasing the number of plates, the height of the plates has to be decreased for maintaining a high resolution. The van Deemter equation is used for defining the effect of different parameters on the height of plate.

Interpretation Introduction

(b)

Interpretation:

The effect of decreasing the rate of sample injection on the plate height needs to be explained.

Concept introduction:

The resolution will increase as the number of plates increases in the GC column. For maintaining a high resolution and increasing the number of plates, the height of the plates must be decreased. For defining the effect of different parameters on the height of plate, van Deemter equation is used.

Interpretation Introduction

(c)

Interpretation:

The effect of increasing the injection port temperature on the plate height needs to be explained.

Concept introduction:

In GC column resolution will increases as the number of plates increases.For maintaining a high resolution and increasing the number of plates, the height of the plates has to be decreased. For defining the dependencies of various parameters on the height of plate, van Deemter equation is used.

Interpretation Introduction

(d)

Interpretation:

The effect of increasing the flow rate on the plate height needs to be explained.

Concept introduction:

As the number of plates increases in a GC column, the resolution would also increase. For increasing the number of plates, the height of the plates has to be decreased for maintaining a high resolution. The van Deemter equation is used for defining the effect of different parameters on the height of plate.

Interpretation Introduction

(e)

Interpretation:

The effect of reducing the particle sizeof the packing on the plate height needs to be explained.

Concept introduction:

The resolution will increase as the number of plates increases in the GC column. For maintaining a high resolution and increasing the number of plates, the height of the plates must be decreased. For defining the effect of different parameters on the height of plate, van Deemter equation is used.

Interpretation Introduction

(f)

Interpretation:

The effect of decreasing the column temperature on the plate height needs to be explained.

Concept introduction:

In GC column resolution will increases as the number of plates increases. For maintaining a high resolution and increasing the number of plates, the height of the plates has to be decreased. For defining the dependencies of various parameters on the height of plate, van Deemter equation is used.

Answer 6

Chapter 27, Problem 27.27QAP

Interpretation Introduction

(a)

Interpretation:

The effect of increasing the mass of stationaryphase relative to the packing masson the plate height needs to be explained.

Concept introduction:

As the number of plates increases in a GC column, the resolution would also increase. For increasing the number of plates, the height of the plates has to be decreased for maintaining a high resolution. The van Deemter equation is used for defining the effect of different parameters on the height of plate.

Answer 7

Chapter 27, Problem 27.27QAP

Interpretation Introduction

(a)

Interpretation:

The effect of increasing the mass of stationaryphase relative to the packing masson the plate height needs to be explained.

Concept introduction:

As the number of plates increases in a GC column, the resolution would also increase. For increasing the number of plates, the height of the plates has to be decreased for maintaining a high resolution. The van Deemter equation is used for defining the effect of different parameters on the height of plate.

Answer 8

Interpretation Introduction

(b)

Interpretation:

The effect of decreasing the rate of sample injection on the plate height needs to be explained.

Concept introduction:

The resolution will increase as the number of plates increases in the GC column. For maintaining a high resolution and increasing the number of plates, the height of the plates must be decreased. For defining the effect of different parameters on the height of plate, van Deemter equation is used.

Answer 9

Interpretation Introduction

(b)

Interpretation:

The effect of decreasing the rate of sample injection on the plate height needs to be explained.

Concept introduction:

The resolution will increase as the number of plates increases in the GC column. For maintaining a high resolution and increasing the number of plates, the height of the plates must be decreased. For defining the effect of different parameters on the height of plate, van Deemter equation is used.

Answer 10

Interpretation Introduction

(c)

Interpretation:

The effect of increasing the injection port temperature on the plate height needs to be explained.

Concept introduction:

In GC column resolution will increases as the number of plates increases.For maintaining a high resolution and increasing the number of plates, the height of the plates has to be decreased. For defining the dependencies of various parameters on the height of plate, van Deemter equation is used.

Answer 11

Interpretation Introduction

(c)

Interpretation:

The effect of increasing the injection port temperature on the plate height needs to be explained.

Concept introduction:

In GC column resolution will increases as the number of plates increases.For maintaining a high resolution and increasing the number of plates, the height of the plates has to be decreased. For defining the dependencies of various parameters on the height of plate, van Deemter equation is used.

Answer 12

Interpretation Introduction

(d)

Interpretation:

The effect of increasing the flow rate on the plate height needs to be explained.

Concept introduction:

As the number of plates increases in a GC column, the resolution would also increase. For increasing the number of plates, the height of the plates has to be decreased for maintaining a high resolution. The van Deemter equation is used for defining the effect of different parameters on the height of plate.

Answer 13

Interpretation Introduction

(d)

Interpretation:

The effect of increasing the flow rate on the plate height needs to be explained.

Concept introduction:

As the number of plates increases in a GC column, the resolution would also increase. For increasing the number of plates, the height of the plates has to be decreased for maintaining a high resolution. The van Deemter equation is used for defining the effect of different parameters on the height of plate.

Answer 14

Interpretation Introduction

(e)

Interpretation:

The effect of reducing the particle sizeof the packing on the plate height needs to be explained.

Concept introduction:

The resolution will increase as the number of plates increases in the GC column. For maintaining a high resolution and increasing the number of plates, the height of the plates must be decreased. For defining the effect of different parameters on the height of plate, van Deemter equation is used.

Answer 15

Interpretation Introduction

(e)

Interpretation:

The effect of reducing the particle sizeof the packing on the plate height needs to be explained.

Concept introduction:

The resolution will increase as the number of plates increases in the GC column. For maintaining a high resolution and increasing the number of plates, the height of the plates must be decreased. For defining the effect of different parameters on the height of plate, van Deemter equation is used.

Answer 16

Interpretation Introduction

(f)

Interpretation:

The effect of decreasing the column temperature on the plate height needs to be explained.

Concept introduction:

In GC column resolution will increases as the number of plates increases. For maintaining a high resolution and increasing the number of plates, the height of the plates has to be decreased. For defining the dependencies of various parameters on the height of plate, van Deemter equation is used.

Answer 17

Interpretation Introduction

(f)

Interpretation:

The effect of decreasing the column temperature on the plate height needs to be explained.

Concept introduction:

In GC column resolution will increases as the number of plates increases. For maintaining a high resolution and increasing the number of plates, the height of the plates has to be decreased. For defining the dependencies of various parameters on the height of plate, van Deemter equation is used.

Answer 18

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Answer 19

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Answer 29

Ch. 27 - Prob. 27.1QAP Ch. 27 - Prob. 27.2QAP Ch. 27 - Prob. 27.3QAP Ch. 27 - Prob. 27.4QAP Ch. 27 - Prob. 27.5QAP Ch. 27 - Prob. 27.6QAP Ch. 27 - Prob. 27.7QAP Ch. 27 - Prob. 27.8QAP Ch. 27 - Prob. 27.9QAP Ch. 27 - What are hyphenated GC methods? Briefly describe...

Chapter 27 Solutions