(a) Interpretation: The structure of each compound involved in the given solid peptide phase synthesis is to be stated. Concept introduction: Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Question

Want to see the full answer?

Answer 1

Question

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

sketch the nature of the metal-alkylidene bonding interactions.

Part C The perspective formula of isoleucine, an amino acid, is provided below. HOOC H₂NIC H 川 CH3 CH,CH3 Draw the Newman projection in staggered conformation for isoleucine by viewing the molecule along the C-2-C-3 bond. 1. Edit the Newman projection on the canvas. 2. Replace the appropriate hydrogens with the appropriate -CH3 or other groups. 3. If you need to start over, Undo or choose a Newman projection from the Templates toolbar (bottom). Important: Never delete the hydrogen atoms or bonds directly attached to the template, and do not move them by dragging or dropping them. That will break the projections structures. Only replace them! ▸ View Available Hint(s) 0 2 H± 3D EXP. L ד י CONT. 2 H 0 N о

Can someone explain this?

Answer 2

Question

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 3

Question

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 5

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 6

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 7

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 8

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 9

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 10

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 11

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 12

Expert Solution & Answer

Answer 13

Expert Solution & Answer

Answer 14

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 15

Ch. 27 - Prob. 27.1P Ch. 27 - Prob. 27.2P Ch. 27 - Prob. 27.3P Ch. 27 - Prob. 27.4P Ch. 27 - Prob. 27.5P Ch. 27 - Prob. 27.6P Ch. 27 - Prob. 27.8P Ch. 27 - Prob. 27.9P Ch. 27 - Prob. 27.10P Ch. 27 - Prob. 27.11P

Solution Summary: The author explains the structure of each compound involved in solid phase peptide synthesis.

Concept explainers

Videos

Want to see the full answer?

Chapter 27 Solutions