Chapter 26.SE, Problem 62AP

Interpretation Introduction

Interpretation:

A mechanism for the first step in the biological degradation of lysine, the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent, is to be proposed.

Concept introduction:

The following steps involved in the reductive amination of lysine with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent. i) The attack of the amino acid N on the carbonyl group of α- ketoglutarate ii) A proton tranfer iii) Elimination of water iv) Reduction by NADPH.

To propose:

A mechanism for the first step in the biological degradation of lysine, the reductive amination with α- ketoglutarate to yield saccharopine using nicotinamide adenine dinucleotide phosphate (NADPH) as the reducing agent.