Chapter 26.SE, Problem 45AP

Interpretation Introduction

a) I-L-P-F

Interpretation:

The structure of the PTH derivative product that is obtained by Edman degradation of the peptide I-L-P-F is to be given.

Concept introduction:

Edmund degradation involves treatment of a peptide with phenyl isothiocyanate, followed by reaction with trifluoroacetic acid when an anilinothiazolinone (ATZ) is produced. This ATZ rearranges in the presence of acids to yield N-phenylthiohydantoin.

To give:

The structure of the PTH derivative product that is obtained by Edman degradation of the peptide I-L-P-F.

Interpretation Introduction

b) D-T-S-G-A

Interpretation:

The structure of the PTH derivative product that is obtained by Edman degradation of the peptide D-T-S-G-A is to be given.

Concept introduction:

Edmund degradation involves treatment of a peptide with phenyl isothiocyanate, followed by reaction with trifluoroacetic acid when an anilinothiazolinone (ATZ) is produced. This ATZ rearranges in the presence of acids to yield N-phenylthiohydantoin.

To give:

The structure of the PTH derivative product that is obtained by Edman degradation of the peptide D-T-S-G-A.