ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
4th Edition
ISBN: 9781266364051
Author: McKinley
Publisher: MCG
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Chapter 26.4, Problem 27WDYL
What is the function of bile salts in lipid digestion? Is this considered chemical digestion or mechanical digestion?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 26 Solutions
ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
Ch. 26.1 - How is the gastrointestinal (GI) tract...Ch. 26.1 - Prob. 2WDYLCh. 26.1 - What specific layer(s) must substances cross to...Ch. 26.1 - Prob. 4WDYLCh. 26.1 - Prob. 5WDYLCh. 26.1 - Prob. 6WDYLCh. 26.1 - Prob. 7WDYLCh. 26.1 - Prob. 8WDYLCh. 26.1 - Prob. 9WDYLCh. 26.2 - What structures are considered part of the upper...
Ch. 26.2 - Prob. 11WDYLCh. 26.2 - Prob. 12WDYLCh. 26.2 - How is the bolus moved from the oral cavity into...Ch. 26.2 - Prob. 14WDYLCh. 26.2 - Prob. 15WDYLCh. 26.3 - What organs are considered part of the lower GI...Ch. 26.3 - What are the three anatomic structures that...Ch. 26.3 - Prob. 18WDYLCh. 26.3 - Diagram the ducts of the accessory digestive...Ch. 26.3 - Prob. 20WDYLCh. 26.3 - Prob. 21WDYLCh. 26.3 - Prob. 22WDYLCh. 26.3 - Prob. 23WDYLCh. 26.3 - Which substances are typically absorbed by the...Ch. 26.4 - What enzymes are required to completely break down...Ch. 26.4 - How are proteolytic enzymes activated in the...Ch. 26.4 - What is the function of bile salts in lipid...Ch. 26.4 - Prob. 28WDYLCh. 26.4 - Prob. 29WDYLCh. 26.4 - Prob. 30WDYLCh. 26 - _____ 1. Which organ is located in the right upper...Ch. 26 - _____ 2. The _____ cells of the stomach are...Ch. 26 - _____ 3. Which of the following is an unregulated...Ch. 26 - _____ 4. Which organ (or part of an organ) is...Ch. 26 - _____ 5. Pancreatic juice contains a. HCO3 and...Ch. 26 - _____ 6. Bile is transported through the a....Ch. 26 - _____ 7. Digestion of proteins begins in the a....Ch. 26 - Prob. 8DYKBCh. 26 - _____ 9. Digestive enzymes that chemically digest...Ch. 26 - _____ 10. Most of the absorption of our digested...Ch. 26 - The GI tract from the esophagus to the anal canal...Ch. 26 - Discuss the reason why the involuntary sequence of...Ch. 26 - Prob. 13DYKBCh. 26 - Compare the structure of the circular folds,...Ch. 26 - Discuss why the tunica mucosa in the colon has a...Ch. 26 - Prob. 16DYKBCh. 26 - What is the role of the gallbladder in digestion?Ch. 26 - Describe the different forms of mechanical...Ch. 26 - Prob. 19DYKBCh. 26 - How are lipids absorbed in the GI tract?Ch. 26 - Prob. 1CALCh. 26 - Prob. 2CALCh. 26 - What component of the digestive tract can you not...Ch. 26 - The pancreatic ducts are blocked with a thick,...Ch. 26 - Prob. 5CALCh. 26 - Alexandra experienced vomiting and diarrhea and...Ch. 26 - A key event in the chemical digestion processes...Ch. 26 - Most cases of colorectal cancer occur in the most...
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