ANAT.+PHYSIO.2-LAB.MAN. >CUSTOM<
20th Edition
ISBN: 9781264303090
Author: VanPutte
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Textbook Question
Chapter 26.3, Problem 29AYP
Describe the roles of the loop of Henle, the vasa recta, and urea cycling in maintaining a high interstitial solute concentration in the kidney medulla.
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The Na+-glucose transporters SGLT2 and SGLT1 are located at different levels of the kidney proximal tubule to minimize spillover of the glucose into the urine (See diagram attached)
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The renal handling of a novel drug is being studied. When the drug is present in the blood, it is filtered into the Bowman’s capsule and secreted via transport proteins in the renal tubules, but it is NOT reabsorbed. The lines on the following graph represent filtration, secretion and excretion rates of this drug at various plasma concentrations.
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Chapter 26 Solutions
ANAT.+PHYSIO.2-LAB.MAN. >CUSTOM<
Ch. 26.1 - Name the organs that make up the urinary system.Ch. 26.1 - List the functions performed by the kidneys, and...Ch. 26.2 - Describe the location, Size, and shown of the...Ch. 26.2 - Describe the renal capsule and the structures that...Ch. 26.2 - List the structures found at the hilum and in the...Ch. 26.2 - What is the functional unit of the kidney? Name...Ch. 26.2 - Distinguish between cortical and juxtamedullary...Ch. 26.2 - List the components of a renal corpuscle.Ch. 26.2 - Describe the structure of the Bowman capsule, the...Ch. 26.2 - Describe the structure of the afferent and...
Ch. 26.2 - Describe the structure and location of the...Ch. 26.2 - Explain blood supply for the kidney.Ch. 26.3 - Name the three general processes involved in...Ch. 26.3 - Contrast the rates of renal blood flow, renal...Ch. 26.3 - Prob. 15AYPCh. 26.3 - What is filtration pressure? How does glomerular...Ch. 26.3 - How do systemic blood pressure and afferent...Ch. 26.3 - Describe autoregulation.Ch. 26.3 - Prob. 19AYPCh. 26.3 - What is the direction of movement of substances in...Ch. 26.3 - Describe what happens to most of the filtrate that...Ch. 26.3 - On what side of therenal tubule cell does active...Ch. 26.3 - Describe how symportworks in the renal tubule.Ch. 26.3 - Name the substances that are moved by active and...Ch. 26.3 - Prob. 25AYPCh. 26.3 - Where does tubular secretion take place? What is...Ch. 26.3 - What substances are secreted? List the mechanisms...Ch. 26.3 - List the major mechanisms that create and maintain...Ch. 26.3 - Describe the roles of the loop of Henle, the vasa...Ch. 26.3 - Describe how the filtrate volume and concentration...Ch. 26.4 - Prob. 31AYPCh. 26.4 - How is angiotensinII activated? What effects does...Ch. 26.4 - Where is aldosterone produced? What factors...Ch. 26.4 - What are the effects of aldosterone on Na+ and CI+...Ch. 26.4 - Where is ADH produced? What factors stimulate an...Ch. 26.4 - How does ADH affect urine volume and...Ch. 26.4 - Describe how the presence of ADH causes the...Ch. 26.4 - How does the absence of ADH cause the production...Ch. 26.4 - Where is atrial natriuretic hormone produced,and...Ch. 26.5 - What is plasma clearance, and how is it...Ch. 26.5 - Prob. 41AYPCh. 26.5 - Describe how PAH is used to determine renal plasma...Ch. 26.5 - Explain the significance of tubular load and...Ch. 26.6 - What are the functions of the ureters, urinary...Ch. 26.6 - Prob. 45AYPCh. 26.6 - Prob. 46AYPCh. 26.6 - Prob. 47AYPCh. 26.6 - Prob. 48AYPCh. 26.7 - Discuss the effect of aging on the kidneys. Why do...Ch. 26 - Prob. 1RACCh. 26 - Prob. 2RACCh. 26 - Prob. 3RACCh. 26 - Prob. 4RACCh. 26 - Prob. 5RACCh. 26 - Prob. 6RACCh. 26 - Prob. 7RACCh. 26 - Prob. 8RACCh. 26 - If the glomerular capillary pressure is 40 mm Hg,...Ch. 26 - Prob. 10RACCh. 26 - Prob. 11RACCh. 26 - Prob. 12RACCh. 26 - Prob. 13RACCh. 26 - Prob. 14RACCh. 26 - Prob. 15RACCh. 26 - Prob. 16RACCh. 26 - Prob. 17RACCh. 26 - Which of the following contributes to the...Ch. 26 - Prob. 19RACCh. 26 - Prob. 20RACCh. 26 - Prob. 21RACCh. 26 - Prob. 22RACCh. 26 - ADH governs the a. Na+ pump of proximal convoluted...Ch. 26 - Prob. 24RACCh. 26 - The amount of a substance that passes through the...Ch. 26 - Prob. 26RACCh. 26 - Prob. 1CTCh. 26 - Harry is doing yard work one hot summer day and...Ch. 26 - Prob. 3CTCh. 26 - Prob. 4CTCh. 26 - Design a kidney that can produce hypostatic urine,...Ch. 26 - If only a very small amount of urea, instead of...Ch. 26 - Prob. 7CTCh. 26 - Marvin was driving too fast on a remote mountain...Ch. 26 - Which of the following will help compensate for...Ch. 26 - Renin-secreting tumors are usually found in the...Ch. 26 - Prob. 11CT
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- Explain how the kidneys help to maintain the balance of acids and bases in extracellular fluid.arrow_forwardWhich of the following does not contribute to the high salt concentration in the interstitial fluid of the kidney medulla? (a) active transport of sodium from the upper part of the ascending limb (b) diffusion of salt from the ascending limb of the loop of Henle (c) reabsorption of salt from various regions of Bowmans capsule (d) counterflow of fluid through the two limbs of the loop of Henle (e) diffusion of urea out of the collecting ductarrow_forwardThe macula densa is/are: present in the renal medulla dense tissue present in the outer layer of the kidney cells present in the DCT and collecting tubules present in blood capillaries.arrow_forward
- One type of diuretic given to people with high blood pressure, renal disease and congestive heart failure are thiazide-type diuretics. These drugs inhibit sodium ion reabsorption by inhibiting the transport in the ascending limb of the loop of Henle. A) What does it mean to inhibit the transport of sodium ions in the loop of Henle? B) Explain how this inhibition of sodium ions in the loop of Henle could help increase urine production.arrow_forwardWhat are the two intrinsic mechanisms that provide auto regulation of glomerular filtrate? Explain any one of these.arrow_forwardAtrial Natriuretic Peptide helps to reduce overall blood pressure in a variety of ways. One way is by increasing Glomerular Filtration Rate. a. Why/how would increasing GFR cause decreased blood pressure? b. To increase GFR, would Atrial Natriuretic Peptide cause constriction or dilation of afferent arterioles at the kidneys? The efferent arterioles?arrow_forward
- Briefly explain the role of kidneys in the following: 1) Excretion of Metabolic Waste Products, Foreign Chemicals, Drugs, and Hormone Metabolites. 2) Regulation of Water and Electrolyte Balance. 3) Regulation of 1,25-dihydroxyvitamin D3 Production.arrow_forwardWhy are the loop of Henle and vasa recta important for the formation of concentrated urine?arrow_forward24. Measurements are made of the renal tubular fluid concentration of various substances along the length of the proximal tubule and plotted as the tubular fluid to plasma concentration ratio (TF/P). As these substances are reabsorbed along with water, the following profiles are obtained. (All substances are freely filtered at the glomerulus, the TF/P = 1 at the glomerulus.) Glucose is represented by which of the following curves? OA) [Tubular fluid] [Plasma] OB) 3.0- 2.0- 1.0- 0 B O C) E 25 50 75 Proximal tubule length (%) OD) 100 OE)arrow_forward
- What are the unique features of Henle loops that contribute to countercurrent multiplication during urine production? Provide an explanation of how countercurrent multiplication is facilitated in nephrons, including all the factors that contribute to it.arrow_forwardRenin is secreted in response to hypovolemia or to an increase in the osmolality of the blood. Provide three possible mechanisms by which these conditions may stimulate rennin secretion. What are the consequences of increased rennin secretion that lead to increased aldosterone secretion? Present this sequence of events. Why are angiotensin converting enzyme inhibitors (ACEIs) used as a common therapy for hypertension? How do they influence blood pressure? Are plasma levels of renin elevated or depressed in a patient with Conn’s disease? Why?arrow_forwardA 28-year-old man has a fasting serum glucose concentration of 140 mg/dL and a glomerular filtration rate of 125 ml/min. The renal transport maximum for glucose in this patient is 300 mg/min. Which of the following best represents the rate of urinary glucose excretion (in mg/min) in this man? (A) 0 (B) 100 (C) 200 (D) 300 (E) 400arrow_forward
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