Biology: The Unity and Diversity of Life (Looseleaf)
15th Edition
ISBN: 9781337408417
Author: STARR
Publisher: CENGAGE L
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Chapter 26, Problem 2DAA
Data Analysis Activities
Neanderthal Hair Color The MC1R gene regulates pigmentation in humans (Sections 13.5 and 14.2), so Loss-of-function mutations in this gene affect hair and skin color. A person with two mutated alleles for this gene makes more of the reddish melanin than the brownish melanin, resu.lti.ng in red hair and pale skin. DNA extracted from two Neanderthal fossils contains a mutated MC1R allele that has not yet been found in humans. To see how the Neanderthal mutation affects the function of the MC1R gene, Carles Lalueza-Fox and her team introduced the allele in to cultured monkey cells (FIGURE 26.12).
FIGURE 26.12 MC1Ractivity. Activity is shown in monkey cells transgenic for an unmutated MC1R gene, the Neanderthal MC1R allele, or the gene for green fluorescent protein (GFP). GFP is not related to MC1R.
What does this imply about the mutation’s effect on Neanderthal hair color?
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Chapter 26 Solutions
Biology: The Unity and Diversity of Life (Looseleaf)
Ch. 26 - Data Analysis Activities Neanderthal Hair Color...Ch. 26 - Data Analysis Activities Neanderthal Hair Color...Ch. 26 - Prob. 3DAACh. 26 - Prob. 1SQCh. 26 - The closest relatives of bonobos are ________. a....Ch. 26 - Prob. 3SQCh. 26 - Prob. 4SQCh. 26 - The 3.6-million-year-old footprints left by...Ch. 26 - The position where a spinal cord enters the skull...Ch. 26 - Prob. 7SQ
Ch. 26 - Prob. 8SQCh. 26 - A prominent chin is typical of _______. a. Homo...Ch. 26 - Prob. 10SQCh. 26 - Prob. 11SQCh. 26 - Prob. 12SQCh. 26 - Prob. 13SQCh. 26 - Match each group with its description. _____...Ch. 26 - Prob. 15SQCh. 26 - Prob. 1CTCh. 26 - Think about the pattern of human dispersal. Given...Ch. 26 - Prob. 3CT
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- Enhanced Spatial Learning Ability in Mice Engineered to Carry an Autism Mutation Autism is a neurobiological disorder with symptoms that include impaired social interactions and repetitive, stereotyped patterns of behavior. Around 10 percent of autistic people also have an extraordinary skill or talent such as greatly enhanced memory. Mutations in the gene for neuroligin 3, an adhesion protein that connects brain cells, have been associated with autism. One of these mutations is called R451C because the altered gene encodes a protein with an amino acid substitution: a cysteine (C) instead of an arginine (R) in position 451. In 2007, Katsuhiko Tabuchi and his colleagues introduced the R451C mutation into the neuroligin 3 gene of mice. The researchers discovered that the genetically modified mice had impaired social behavior and superior spatial learning ability. Spatial learning in mice is tested with a water maze, which consists of a small platform submerged a bit below the surface or a pool of water so it is invisible to a swimming mouse. Mice do not particularly enjoy swimming, so they try to locate the hidden platform as quickly as they can. When tested again later, they remember the platforms location by checking visual cues around the edge or the pool. How quickly they remember is a measure of their spatial learning ability. FIGURE 15.14 shows some or Tabuchis result. FIGURE 15.14 Spatial learning ability in mice. Mice with a mutation in neuroligin 3 (R451C) were tested for learning performance: as compared with unmodified (wild-type) mice. Did the modified or the unmodified mice learn the location of the platform faster in the first test?arrow_forwardEnhanced Spatial Learning in Mice With an Autism Mutation Autism is a neurobiological disorder with symptoms that include impaired social interactions and stereotyped patterns of behavior. Around 10 percent of autistic people have an extraordinary skill or talent such as greatly enhanced memory. Mutations in neuroligin 3, an adhesion protein that connects brain cells to one another, have been associated with autism. One mutation changes amino acid 451 from arginine to cysteine. In 2007, Katsuhiko Tabuchi and his colleagues genetically modified mice to carry the same arginine-to-cysteine substitution in their neuroligin 3. Mice with the mutation had impaired social behavior. To test spatial learning ability, the mice were placed in a water maze: a deep pool of warm water in which a platform is submerged a few millimeters below the surface. The platform is not visible to swimming mice. Mice do not particularly enjoy swimming, so they locate a hidden platform as fast as they can. When tested again, they can remember its location by checking visual cues around the edge of the pool. How quickly they remember the platforms location is a measure of spatial learning ability (FIGURE 15.18). FIGURE 15.18 spatial learning ability in mica mutation in neuroligin 3 (R451C), compared with unmodified (wild-type) mica. 1. In the first, how many days did it take unmodified mice to learn to find the location of the hidden platform within 10 seconds?arrow_forwardcharacteristics Part 1: Function of Protein Sunthesis and Gene Expression protein trait It's in your genes.... hair color plant helght, freckles for a Genes are sections of DNA that 18 that give us a A trait is different o Ex: Another day at the job.. The main job of every cell is to make Proteins are made up of many amino acids (their monomers) macromblecules proteins Part 2: DNAarrow_forward
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