The nucleoside from which cordycepin is derived. Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus , Cordyceps militaris . It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

Question

Want to see more full solutions like this?

Answer 1

Question

Chapter 26, Problem 1E

(a)

Summary Introduction

To determine: The nucleoside from which cordycepin is derived.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(a)

Expert Solution

Answer to Problem 1E

Correct answer: Cordycepin is the 3ʹ-deoxy analog of adenosine.

Explanation of Solution

Explanation:

Cordycepin is also known as 3ʹ-deoxyadenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. Cordycepin is a derivative of Adenosine. The only difference between them is that cordycepin lacks 3ʹ-hydroxyl group. Thus, cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine.

(b)

Summary Introduction

To explain: The mechanism of action of cordycepin.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(b)

Expert Solution

Explanation of Solution

Explanation:

Cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. During RNA synthesis, certain enzymes are unable to differentiate between adenosine and Cordycepin. This leads to an incorporation of Cordycepin (3ʹ-deoxyadenosine) into the growing RNA chain in the place of normal nitrogenous bases. Since Cordycepin lacks 3ʹ-hydroxyl group, further elongation of RNA chain will be terminated in 5ʹ-3ʹ direction. As a result, premature termination of transcription would occur.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Students have asked these similar questions

Calculate the number of ATP produced from oxidation of 1 molecule of glucose

Example 1: 1. Suppose an enzyme (MW = 5,000 g/mole) has a concentration of 0.05 mg/L. If the kcat is 1 x 10 s, what is the theoretical maximum reaction velocity for the enzyme? A) 1050 µM/s. B) 100 µM/s. C) 150 μM/s. D) 105 μM/s.

In 1956, E. P. Kennedy and S. B. Weiss published their study of membrane lipid phosphatidylcholine (lecithin) synthesis in rat liver. Their hypothesis was that phosphocholine joined with some cellular component to yield lecithin. In an earlier experiment, incubating 32 P-labeled phosphocholine at physiological temperature (37 °C) with broken cells from rat liver yielded labeled lecithin. This became their assay for the enzymes involved in lecithin synthesis. Determine the optimal pH for this enzyme and characterize the enzyme activity at different pH values. -O-P-O-CH2-CH₁₂-N(CH3)3 Phosphocholine H₂C-O-C-R HC-O-C-R2 + + + Cell fraction + ? HC-O-P-O-CH₁₂-CH₂-N(CH), O Phosphatidylcholine The researchers then centrifuged the broken cell preparation to separate the membranes from the soluble proteins. They tested three preparations: whole extract, membranes, and soluble proteins. Table 1 summarizes the results. Table 1: Cell fraction requirement for incorporation of 32p-phosphocholine into…

Answer 2

Question

Chapter 26, Problem 1E

(a)

Summary Introduction

To determine: The nucleoside from which cordycepin is derived.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(a)

Expert Solution

Answer to Problem 1E

Correct answer: Cordycepin is the 3ʹ-deoxy analog of adenosine.

Explanation of Solution

Explanation:

Cordycepin is also known as 3ʹ-deoxyadenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. Cordycepin is a derivative of Adenosine. The only difference between them is that cordycepin lacks 3ʹ-hydroxyl group. Thus, cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine.

(b)

Summary Introduction

To explain: The mechanism of action of cordycepin.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(b)

Expert Solution

Explanation of Solution

Explanation:

Cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. During RNA synthesis, certain enzymes are unable to differentiate between adenosine and Cordycepin. This leads to an incorporation of Cordycepin (3ʹ-deoxyadenosine) into the growing RNA chain in the place of normal nitrogenous bases. Since Cordycepin lacks 3ʹ-hydroxyl group, further elongation of RNA chain will be terminated in 5ʹ-3ʹ direction. As a result, premature termination of transcription would occur.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 3

Question

Chapter 26, Problem 1E

(a)

Summary Introduction

To determine: The nucleoside from which cordycepin is derived.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(a)

Expert Solution

Answer to Problem 1E

Correct answer: Cordycepin is the 3ʹ-deoxy analog of adenosine.

Explanation of Solution

Explanation:

Cordycepin is also known as 3ʹ-deoxyadenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. Cordycepin is a derivative of Adenosine. The only difference between them is that cordycepin lacks 3ʹ-hydroxyl group. Thus, cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine.

(b)

Summary Introduction

To explain: The mechanism of action of cordycepin.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(b)

Expert Solution

Explanation of Solution

Explanation:

Cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. During RNA synthesis, certain enzymes are unable to differentiate between adenosine and Cordycepin. This leads to an incorporation of Cordycepin (3ʹ-deoxyadenosine) into the growing RNA chain in the place of normal nitrogenous bases. Since Cordycepin lacks 3ʹ-hydroxyl group, further elongation of RNA chain will be terminated in 5ʹ-3ʹ direction. As a result, premature termination of transcription would occur.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 4

Question

Chapter 26, Problem 1E

(a)

Summary Introduction

To determine: The nucleoside from which cordycepin is derived.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(a)

Expert Solution

Answer to Problem 1E

Correct answer: Cordycepin is the 3ʹ-deoxy analog of adenosine.

Explanation of Solution

Explanation:

Cordycepin is also known as 3ʹ-deoxyadenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. Cordycepin is a derivative of Adenosine. The only difference between them is that cordycepin lacks 3ʹ-hydroxyl group. Thus, cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine.

(b)

Summary Introduction

To explain: The mechanism of action of cordycepin.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(b)

Expert Solution

Explanation of Solution

Explanation:

Cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. During RNA synthesis, certain enzymes are unable to differentiate between adenosine and Cordycepin. This leads to an incorporation of Cordycepin (3ʹ-deoxyadenosine) into the growing RNA chain in the place of normal nitrogenous bases. Since Cordycepin lacks 3ʹ-hydroxyl group, further elongation of RNA chain will be terminated in 5ʹ-3ʹ direction. As a result, premature termination of transcription would occur.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 5

Chapter 26, Problem 1E

(a)

Summary Introduction

To determine: The nucleoside from which cordycepin is derived.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(a)

Expert Solution

Answer to Problem 1E

Correct answer: Cordycepin is the 3ʹ-deoxy analog of adenosine.

Explanation of Solution

Explanation:

Cordycepin is also known as 3ʹ-deoxyadenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. Cordycepin is a derivative of Adenosine. The only difference between them is that cordycepin lacks 3ʹ-hydroxyl group. Thus, cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine.

(b)

Summary Introduction

To explain: The mechanism of action of cordycepin.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(b)

Expert Solution

Explanation of Solution

Explanation:

Cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. During RNA synthesis, certain enzymes are unable to differentiate between adenosine and Cordycepin. This leads to an incorporation of Cordycepin (3ʹ-deoxyadenosine) into the growing RNA chain in the place of normal nitrogenous bases. Since Cordycepin lacks 3ʹ-hydroxyl group, further elongation of RNA chain will be terminated in 5ʹ-3ʹ direction. As a result, premature termination of transcription would occur.

Answer 6

Chapter 26, Problem 1E

(a)

Summary Introduction

To determine: The nucleoside from which cordycepin is derived.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(a)

Expert Solution

Answer to Problem 1E

Correct answer: Cordycepin is the 3ʹ-deoxy analog of adenosine.

Explanation of Solution

Explanation:

Cordycepin is also known as 3ʹ-deoxyadenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. Cordycepin is a derivative of Adenosine. The only difference between them is that cordycepin lacks 3ʹ-hydroxyl group. Thus, cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine.

Answer 7

Chapter 26, Problem 1E

(a)

Summary Introduction

To determine: The nucleoside from which cordycepin is derived.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

Answer 8

(a)

Expert Solution

Answer to Problem 1E

Correct answer: Cordycepin is the 3ʹ-deoxy analog of adenosine.

Answer 9

(a)

Expert Solution

Answer 10

(a)

Expert Solution

Answer 11

Expert Solution

Answer 12

Explanation of Solution

Explanation:

Cordycepin is also known as 3ʹ-deoxyadenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. Cordycepin is a derivative of Adenosine. The only difference between them is that cordycepin lacks 3ʹ-hydroxyl group. Thus, cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine.

Answer 13

(b)

Summary Introduction

To explain: The mechanism of action of cordycepin.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(b)

Expert Solution

Explanation of Solution

Explanation:

Cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. During RNA synthesis, certain enzymes are unable to differentiate between adenosine and Cordycepin. This leads to an incorporation of Cordycepin (3ʹ-deoxyadenosine) into the growing RNA chain in the place of normal nitrogenous bases. Since Cordycepin lacks 3ʹ-hydroxyl group, further elongation of RNA chain will be terminated in 5ʹ-3ʹ direction. As a result, premature termination of transcription would occur.

Answer 14

(b)

Summary Introduction

To explain: The mechanism of action of cordycepin.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

Answer 15

(b)

Expert Solution

Explanation of Solution

Explanation:

Cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. During RNA synthesis, certain enzymes are unable to differentiate between adenosine and Cordycepin. This leads to an incorporation of Cordycepin (3ʹ-deoxyadenosine) into the growing RNA chain in the place of normal nitrogenous bases. Since Cordycepin lacks 3ʹ-hydroxyl group, further elongation of RNA chain will be terminated in 5ʹ-3ʹ direction. As a result, premature termination of transcription would occur.