Phe-Leu-Val-Phe and Ala-Val-Leu-Ile was synthesized using Merrifield synthesis and the steps used for the synthesis has to be identified. Concept introduction: Peptides can be synthesized in more yield by using the method developed by R. Bruce Merrifield. A peptide containing a large number of amino acid residue can be synthesized easily by this method. The coupling of the amino acid residues are done without purification. The key steps involved in Merrifield Synthesis are, Attachment of Boc-protected residue to polymer . Removal of Boc Protecting group. Coupling with another Boc-protected amino acid using DCC. For each amino acid that is added to the growing peptide chain removal of Boc and coupling is done. Removal of Boc and detachment of peptide from the polymer. To identify : To identify all the steps used to prepare Phe-Leu-Val-Phe via Merrifield synthesis.

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Answer 1

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Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 25.6, Problem 37PTS

(a)

Interpretation Introduction

Interpretation:

Phe-Leu-Val-Phe and Ala-Val-Leu-Ile was synthesized using Merrifield synthesis and the steps used for the synthesis has to be identified.

Concept introduction:

Peptides can be synthesized in more yield by using the method developed by R. Bruce Merrifield. A peptide containing a large number of amino acid residue can be synthesized easily by this method. The coupling of the amino acid residues are done without purification. The key steps involved in Merrifield Synthesis are,

Attachment of Boc-protected residue to polymer.

Removal of Boc Protecting group.

Coupling with another Boc-protected amino acid using DCC.

For each amino acid that is added to the growing peptide chain removal of Boc and coupling is done.

Removal of Boc and detachment of peptide from the polymer.

To identify: To identify all the steps used to prepare Phe-Leu-Val-Phe via Merrifield synthesis.

(b)

Interpretation Introduction

Interpretation:

Phe-Leu-Val-Phe and Ala-Val-Leu-Ile was synthesized using Merrifield synthesis and the steps used for the synthesis has to be identified.

Concept introduction:

Peptides can be synthesized in more yield by using the method developed by R. Bruce Merrifield. A peptide containing a large number of amino acid residue can be synthesized easily by this method. The coupling of the amino acid residues are done without purification. The key steps involved in Merrifield Synthesis are,

Attachment of Boc-protected residue to polymer.

Removal of Boc Protecting group.

Coupling with another Boc-protected amino acid using DCC.

For each amino acid that is added to the growing peptide chain removal of Boc and coupling is done.

Removal of Boc and detachment of peptide from the polymer.

To identify: To identify all the steps used to prepare Ala-Val-Leu-Ile via Merrifield synthesis.

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Г C-RSA CHROMATOPAC CH=1 DATA 1: @CHRM1.C00 ATTEN=10 SPEED= 10.0 0.0 b.092 0.797 1.088 1.813 C-RSA CHROMATOPAC CH=1 Report No. =13 ** CALCULATION REPORT ** DATA=1: @CHRM1.000 11/03/05 08:09:52 CH PKNO TIME 1 2 0.797 3 1.088 4 1.813 AREA 1508566 4625442 2180060 HEIGHT 207739 701206 V 287554 V MK IDNO CONC NAME 18.1447 55.6339 26.2213 TOTAL 8314067 1196500 100 C-R8A CHROMATOPAC CH=1 DATA 1: @CHRM1.C00 ATTEN=10 SPEED= 10.0 0. 0 087 337. 0.841 1.150 C-R8A CHROMATOPAC CH=1 Report No. =14 DATA=1: @CHRM1.000 11/03/05 08:12:40 ** CALCULATION REPORT ** CH PKNO TIME AREA 1 3 0.841 1099933 41.15 4039778 HEIGHT MK IDNO 170372 649997¯¯¯ CONC NAME 21.4007 78.5993 TOTAL 5139711 820369 100 3 C-R8A CHROMATOPAC CH=1 DATA 1: @CHRM1.C00 ATTEN=10 SPEED= 10.0 0.100 0:652 5.856 3 1.165 C-RSA CHROMATOPAC CH-1 Report No. =15 DATA=1: @CHRM1.000 11/03/05 08:15:26 ** CALCULATION REPORT ** CH PKNO TIME AREA HEIGHT MK IDNO CONC NAME 1 3 3 0.856 4 1.165 TOTAL 1253386 4838738 175481 708024 V 20.5739 79.4261 6092124…

Draw the product of the reaction shown below. Ignore small byproducts that would evaporate please.

Relative Abundance 20- Problems 501 (b) The infrared spectrum has a medium-intensity peak at about 1650 cm. There is also a C-H out-of-plane bending peak near 880 cm. 100- 80- 56 41 69 M(84) LL 15 20 25 30 35 55 60 65 70 75 80 85 90 m/z

Answer 2

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 25.6, Problem 37PTS

(a)

Interpretation Introduction

Interpretation:

Phe-Leu-Val-Phe and Ala-Val-Leu-Ile was synthesized using Merrifield synthesis and the steps used for the synthesis has to be identified.

Concept introduction:

Peptides can be synthesized in more yield by using the method developed by R. Bruce Merrifield. A peptide containing a large number of amino acid residue can be synthesized easily by this method. The coupling of the amino acid residues are done without purification. The key steps involved in Merrifield Synthesis are,

Attachment of Boc-protected residue to polymer.

Removal of Boc Protecting group.

Coupling with another Boc-protected amino acid using DCC.

For each amino acid that is added to the growing peptide chain removal of Boc and coupling is done.

Removal of Boc and detachment of peptide from the polymer.

To identify: To identify all the steps used to prepare Phe-Leu-Val-Phe via Merrifield synthesis.

(b)

Interpretation Introduction

Interpretation:

Phe-Leu-Val-Phe and Ala-Val-Leu-Ile was synthesized using Merrifield synthesis and the steps used for the synthesis has to be identified.

Concept introduction:

Peptides can be synthesized in more yield by using the method developed by R. Bruce Merrifield. A peptide containing a large number of amino acid residue can be synthesized easily by this method. The coupling of the amino acid residues are done without purification. The key steps involved in Merrifield Synthesis are,

Attachment of Boc-protected residue to polymer.

Removal of Boc Protecting group.

Coupling with another Boc-protected amino acid using DCC.

For each amino acid that is added to the growing peptide chain removal of Boc and coupling is done.

Removal of Boc and detachment of peptide from the polymer.

To identify: To identify all the steps used to prepare Ala-Val-Leu-Ile via Merrifield synthesis.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 3

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 25.6, Problem 37PTS

(a)

Interpretation Introduction

Interpretation:

Phe-Leu-Val-Phe and Ala-Val-Leu-Ile was synthesized using Merrifield synthesis and the steps used for the synthesis has to be identified.

Concept introduction:

Peptides can be synthesized in more yield by using the method developed by R. Bruce Merrifield. A peptide containing a large number of amino acid residue can be synthesized easily by this method. The coupling of the amino acid residues are done without purification. The key steps involved in Merrifield Synthesis are,

Attachment of Boc-protected residue to polymer.

Removal of Boc Protecting group.

Coupling with another Boc-protected amino acid using DCC.

For each amino acid that is added to the growing peptide chain removal of Boc and coupling is done.

Removal of Boc and detachment of peptide from the polymer.

To identify: To identify all the steps used to prepare Phe-Leu-Val-Phe via Merrifield synthesis.

(b)

Interpretation Introduction

Interpretation:

Phe-Leu-Val-Phe and Ala-Val-Leu-Ile was synthesized using Merrifield synthesis and the steps used for the synthesis has to be identified.

Concept introduction:

Peptides can be synthesized in more yield by using the method developed by R. Bruce Merrifield. A peptide containing a large number of amino acid residue can be synthesized easily by this method. The coupling of the amino acid residues are done without purification. The key steps involved in Merrifield Synthesis are,

Attachment of Boc-protected residue to polymer.

Removal of Boc Protecting group.

Coupling with another Boc-protected amino acid using DCC.

For each amino acid that is added to the growing peptide chain removal of Boc and coupling is done.

Removal of Boc and detachment of peptide from the polymer.

To identify: To identify all the steps used to prepare Ala-Val-Leu-Ile via Merrifield synthesis.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 25.6, Problem 37PTS

(a)

Interpretation Introduction