LSC TOMBALL BIOLOGY CONNECT ACCESS
14th Edition
ISBN: 9781265728496
Author: Mader
Publisher: MCG CUSTOM
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Textbook Question
Chapter 25.3, Problem 2CYP
Describe the movement of information from the nucleus to the formation of a functional protein.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 25 Solutions
LSC TOMBALL BIOLOGY CONNECT ACCESS
Ch. 25.1 - Summarize the experiment that enabled scientist to...Ch. 25.1 - Prob. 2LOCh. 25.1 - Summarize the significance off the Griffith and...Ch. 25.1 - Prob. 2CYPCh. 25.1 - Prob. 3CYPCh. 25.1 - Based on Chargaff’s rules, if a segment of DNA is...Ch. 25.1 - Watson and Crick’s discovery of DNA is clearly one...Ch. 25.1 - Prob. 3QTCCh. 25.2 - Prob. 1LOCh. 25.2 - Prob. 2LO
Ch. 25.2 - Explain why DNA replication is said to be...Ch. 25.2 - Prob. 2CYPCh. 25.3 - Describe the role of RNA molecules in gene...Ch. 25.3 - Prob. 2LOCh. 25.3 - Prob. 3LOCh. 25.3 - Prob. 4LOCh. 25.3 - Prob. 1CYPCh. 25.3 - Describe the movement of information from the...Ch. 25.3 - Discuss why the genetic code is said to be...Ch. 25.4 - Prob. 1LOCh. 25.4 - Prob. 2LOCh. 25.4 - Prob. 3LOCh. 25.4 - Prob. 1CYPCh. 25.4 - Prob. 2CYPCh. 25.4 - Prob. 3CYPCh. 25.5 - Summarize the causes of gene mutations.Ch. 25.5 - Prob. 2LOCh. 25.5 - Prob. 3LOCh. 25.5 - Which of these cancer preventive measures are you...Ch. 25.5 - Why do you think tobacco use increase the risk of...Ch. 25.5 - Why does the use of tanning beds also increase the...Ch. 25.5 - Prob. 1CYPCh. 25.5 - Prob. 2CYPCh. 25.5 - Prob. 3CYPCh. 25.5 - Prob. 1AQTCCh. 25.5 - Prob. 2AQTCCh. 25.5 - Prob. 3AQTCCh. 25 - Prob. F2.6BYBCh. 25 - Section 2.8 How does the structure of DNA differ...Ch. 25 - Prob. S23.1BYBCh. 25 - How is that information in the DNA interpreted...Ch. 25 - How might mutation in the DNA result in the...Ch. 25 - Prob. 1ACh. 25 - Prob. 2ACh. 25 - Prob. 3ACh. 25 - Prob. 4ACh. 25 - Prob. 5ACh. 25 - Prob. 6ACh. 25 - Prob. 7ACh. 25 - Prob. 8ACh. 25 - Prob. 9ACh. 25 - Prob. 10ACh. 25 - Prob. 11ACh. 25 - Prob. 12ACh. 25 - Prob. 13ACh. 25 - Prob. 14ACh. 25 - Prob. 15ACh. 25 - Prob. 1TCCh. 25 - Prob. 2TCCh. 25 - Prob. 3TC
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