CAMPBELL'S BIOLOGY MASTERING BIOLOGY
12th Edition
ISBN: 9780135855843
Author: Urry
Publisher: PEARSON
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Chapter 25, Problem 8TYU
EVOLUTION CONNECTION Describe how gene flow, genetic drift, and natural sclection all can influence macroevolution.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 25 Solutions
CAMPBELL'S BIOLOGY MASTERING BIOLOGY
Ch. 25.1 - What hypothesis did Miller test in his classic...Ch. 25.1 - How would the appearance of protocells have...Ch. 25.1 - MAKE CONNECTIONS In changing from an "RNA world"...Ch. 25.2 - Describe an example from the fossil record that...Ch. 25.2 - WHAT IF? Your measurements indicate that a...Ch. 25.3 - The first appearance of free oxygen in the...Ch. 25.3 - What evidence supports the hypothesis that...Ch. 25.3 - WHAT IF? What would a fossil record of life today...Ch. 25.4 - Explain the consequences of plate tectonics for...Ch. 25.4 - What factors promote adaptive radiations?
Ch. 25.4 - Prob. 3CCCh. 25.5 - Explain how new body forms can originate by...Ch. 25.5 - Why is it likely that Hox genes have played a...Ch. 25.5 - Prob. 3CCCh. 25.6 - How can the Darwinian concept of descent with...Ch. 25.6 - Prob. 2CCCh. 25 - Describe the roles that montmorillonite clay and...Ch. 25 - What are the challenges of estimating the ages of...Ch. 25 - What is the "Cambrian explosion," and why is it...Ch. 25 - Explain how the broad evolutionary changes seen in...Ch. 25 - How could changes in a Single gene or DNA region...Ch. 25 - Explain the reasoning behind the Statement...Ch. 25 - Level 1: Knowledge/Comprehension 1. Fossilized...Ch. 25 - The oxygen revolution changed Earth's environment...Ch. 25 - Prob. 3TYUCh. 25 - Prob. 4TYUCh. 25 - Prob. 5TYUCh. 25 - Prob. 6TYUCh. 25 - Prob. 7TYUCh. 25 - EVOLUTION CONNECTION Describe how gene flow,...Ch. 25 - Prob. 9TYUCh. 25 - WRITE ABOUT A THEME: ORGANIZATION You have seen...Ch. 25 - Prob. 11TYU
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