Human Anatomy & Physiology (2nd Edition)
2nd Edition
ISBN: 9780134553511
Author: Erin C. Amerman
Publisher: PEARSON
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Chapter 2.5, Problem 7QC
Summary Introduction
To review:
The four components present in amino acids.
Introduction:
Amino acids are the basis for the synthesis of proteins through the translation process. They act as a monomer of proteins. About 21 different types of amino acids are present, which make all the proteins inside the body.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 2 Solutions
Human Anatomy & Physiology (2nd Edition)
Ch. 2.1 - What are atoms?Ch. 2.1 - How do the three types of subatomic particles...Ch. 2.1 - What is an element?Ch. 2.1 - 4. How are elements arranged in the periodic...Ch. 2.1 - What are isotopes?Ch. 2.2 - What is a mixture?Ch. 2.2 - 2. How do the three types of mixtures differ?
Ch. 2.2 - Prob. 3QCCh. 2.2 - What is an ionic bond?Ch. 2.2 - 5. How is an ionic bond formed?
Ch. 2.2 - 6. How do polar and nonpolar covalent bonds...Ch. 2.2 - What are hydrogen bonds? Between which types of...Ch. 2.3 - Prob. 1QCCh. 2.3 - What are the differences between the three types...Ch. 2.3 - How do endergonic and exergonic reactions differ?Ch. 2.3 - 4. What are the differences between the three main...Ch. 2.3 - What factors can influence the rate of a chemical...Ch. 2.3 - 6. What is an enzyme, and what is its function?
Ch. 2.4 - What four properties of water make it a good...Ch. 2.4 - 2. Which molecules or compounds are likely to be...Ch. 2.4 - What are acids and bases?Ch. 2.4 - What is the pH scale? Which pH values are...Ch. 2.4 - What is the effect of a buffer on a solution?Ch. 2.4 - What is a salt?Ch. 2.4 - 7. What does an electrolyte do in a solution?
Ch. 2.5 - 1. How do polymers and monomers differ?
Ch. 2.5 - 2. How do monosaccharides, disaccharides, and...Ch. 2.5 - How are two monosaccharides linked to form a...Ch. 2.5 - Prob. 4QCCh. 2.5 - 5. How do phospholipids and triglycerides differ?
Ch. 2.5 - What are steroids?Ch. 2.5 - Prob. 7QCCh. 2.5 - How are amino acids linked to form peptides and...Ch. 2.5 - 9. What are the four levels of structural...Ch. 2.5 - 10. What are the components and roles of ATP?
Ch. 2.5 - 11. How do DNA and RNA differ?
Ch. 2 - Prob. 1CYRCh. 2 - Fill in the blanks: Isotopes are atoms with the...Ch. 2 - 3. Which of the following statements correctly...Ch. 2 - 4. Explain the difference between an ionic and a...Ch. 2 - Identify each of the following molecules or...Ch. 2 - What are hydrogen bonds, and how do they form?Ch. 2 - Prob. 7CYRCh. 2 - Prob. 8CYRCh. 2 - Which of the following would not result in an...Ch. 2 - 10. An enzyme is a:
a. biological catalyst that...Ch. 2 - Prob. 11CYRCh. 2 - With respect to their solubility in water,...Ch. 2 - Mark the following statements as true or false. If...Ch. 2 - A salt is: a. a metal cation bonded to a nonmetal...Ch. 2 - 15. Compare and contrast the structures of...Ch. 2 - 16. Mark the following statements as true or...Ch. 2 - 17. Why is it important for a protein to maintain...Ch. 2 - Which of the following is not part of a...Ch. 2 - 19. Mark the following properties as belonging to...Ch. 2 - Which of the following statements is/are true...Ch. 2 - 1. In certain types of radioactive decay, the...Ch. 2 - Considering that water is a main component of the...Ch. 2 - 3. Explain why monosaccharides are polar and fatty...Ch. 2 - 1. The polysaccharide cellulose is not digestible...Ch. 2 - Some claim that the pH of your blood can be...Ch. 2 - Prob. 3AYKACh. 2 - Prob. 4AYKB
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