Campbell Biology In Focus
2nd Edition
ISBN: 9780134203072
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece
Publisher: PEARSON
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Chapter 25, Problem 6TYU
Based on the phylogenetic tree in Figure 25.9, which of the following statements is correct?
- A. The most recent common ancestor of Excavata is older than that of SAR.
- B. The most recent common ancestor of red algae and plants is older than that of nucleariids and
fungi . - C. The most basal (first to diverge) eukaryotic supergroup cannot be determined.
- D. Excavata is the most basal eukaryotic supergroup.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 25 Solutions
Campbell Biology In Focus
Ch. 25.1 - Describe major events in the evolution of early...Ch. 25.1 - Explain why eukaryotes are said to be combination...Ch. 25.1 - Prob. 3CCCh. 25.2 - Summarize the evidence that choanoflagellates are...Ch. 25.2 - MAKE CONNECTlONS Describe how the origin of...Ch. 25.2 - Prob. 3CCCh. 25.3 - Briefly describe the organisms found in each of...Ch. 25.3 - MAKE CONNECTIONS Review Figures 7.2 and 8.5...Ch. 25.3 - Prob. 3CCCh. 25.4 - Justify the claim that photosynthetic protists are...
Ch. 25.4 - Prob. 2CCCh. 25.4 - Prob. 3CCCh. 25 - The oldest fossil eukaryote that can be resolved...Ch. 25 - Prob. 2TYUCh. 25 - Plastids that are surrounded by more than two...Ch. 25 - Prob. 4TYUCh. 25 - Prob. 5TYUCh. 25 - Based on the phylogenetic tree in Figure 25.9,...Ch. 25 - MAKE CONNECTIONS The bacterium Wolbachia is a...Ch. 25 - FOCUS ON EVOLUTION DRAW IT Medical researchers...Ch. 25 - FOCUS ON INTERACTIONS Organisms interact with each...Ch. 25 - SYNTHESIZE YOUR KNOWLEDGE These micrographs show...
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