ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
4th Edition
ISBN: 9781266364051
Author: McKinley
Publisher: MCG
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Chapter 25, Problem 4CAL
Harold has been suffering from diabetes mellitus for approximately 15 years. As a result of having recently lost his job and being under a great deal of stress, and he has not been adequately managing his diabetes. His breath smells sweet, a sign of producing ketoacids. Harold is most likely suffering from which type of pH imbalance?
- a. respiratory acidosis
- b.
metabolic acidosis - c. respiratory alkalosis
- d. metabolic alkalosis
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 25 Solutions
ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
Ch. 25.1 - Prob. 1WDYLCh. 25.1 - Which ions are more prevalent in the intracellular...Ch. 25.1 - What is the major distinction in the chemical...Ch. 25.1 - Prob. 4WDYLCh. 25.2 - What are the two major sources of fluid intake?...Ch. 25.2 - How would you distinguish fluid deficiency from...Ch. 25.2 - Prob. 7WDYLCh. 25.2 - Which of these four hormonesangiotensin II,...Ch. 25.3 - Why do electrolytes exert a greater osmotic...Ch. 25.3 - Prob. 10WDYL
Ch. 25.4 - Prob. 11WDYLCh. 25.4 - How does the homeostatic system involving ADH...Ch. 25.4 - Prob. 13WDYLCh. 25.4 - Prob. 14WDYLCh. 25.5 - What is meant by acid-base balance?Ch. 25.5 - How are fixed acids distinguished from volatile...Ch. 25.5 - How do the kidneys regulate fixed acids to help...Ch. 25.5 - Prob. 18WDYLCh. 25.5 - What are the three chemical buffering systems, and...Ch. 25.5 - Prob. 20WDYLCh. 25.6 - Prob. 21WDYLCh. 25.6 - Prob. 22WDYLCh. 25.6 - Prob. 23WDYLCh. 25.6 - Prob. 24WDYLCh. 25.6 - Prob. 25WDYLCh. 25.6 - Prob. 26WDYLCh. 25 - Prob. 1DYKBCh. 25 - _____ 2. The fluid compartment with the largest...Ch. 25 - _____3. Which of the following would result in...Ch. 25 - _____4. If an individual has decreased saliva...Ch. 25 - _____5. Which hormone decreases total body fluid,...Ch. 25 - Which of the following describes an electrolyte?...Ch. 25 - Prob. 7DYKBCh. 25 - Prob. 8DYKBCh. 25 - Which of the following is not a chemical buffer in...Ch. 25 - Prob. 10DYKBCh. 25 - List the three variables that determine the...Ch. 25 - Describe the movement of water between the...Ch. 25 - Prob. 13DYKBCh. 25 - Explain the homeostatic system involving the renin...Ch. 25 - Describe how ANP is regulated and how it opposes...Ch. 25 - Describe the functions of Na+ and how it is...Ch. 25 - Describe what occurs in the kidney to maintain...Ch. 25 - Prob. 18DYKBCh. 25 - List the three chemical buffers, and describe how...Ch. 25 - Describe respiratory acidosis and its...Ch. 25 - Maria brings her baby to the emergency room. She...Ch. 25 - Prob. 2CALCh. 25 - Prob. 3CALCh. 25 - Harold has been suffering from diabetes mellitus...Ch. 25 - Prob. 5CALCh. 25 - Morgan is a nurse at the local hospital. She...Ch. 25 - Ms. Taylor, 68 years old, has been vomiting for 2...Ch. 25 - Prob. 3CSL
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