Microbiology With Diseases By Taxonomy (6th Edition)
6th Edition
ISBN: 9780134832302
Author: Robert W. Bauman Ph.D.
Publisher: PEARSON
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Chapter 25, Problem 2CT
A 20-year-old man is brought to a South Carolina hospital’s emergency room suffering from seizures, disorientation, hallucinations, and an inordinate fear of water. His family members report that he had suffered with fever and headache for several days. The patient had been bitten by a dog approximately 12 days before admission. What disease does the patient have? Will a vaccine be an effective treatment? If the dog is found to be disease free, what wild animals are the likely source of infection in South Carolina? What treatment should the patient's family, coworkers, friends, and caregivers receive?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 25 Solutions
Microbiology With Diseases By Taxonomy (6th Edition)
Ch. 25 - Why might enteroviruses, which infect the body...Ch. 25 - Prob. 2TMWCh. 25 - Prob. 3TMWCh. 25 - Prob. 4TMWCh. 25 - Prob. 5TMWCh. 25 - Prob. 6TMWCh. 25 - A man arrived at an emergency room with...Ch. 25 - Prob. 1EDCSCh. 25 - Prob. 2EDCSCh. 25 - Prob. 1MC
Ch. 25 - What do viruses in the families Picornaviridae,...Ch. 25 - Prob. 3MCCh. 25 - Prob. 4MCCh. 25 - Prob. 5MCCh. 25 - Prob. 6MCCh. 25 - Prob. 7MCCh. 25 - Prob. 8MCCh. 25 - Prob. 9MCCh. 25 - Prob. 10MCCh. 25 - Prob. 11MCCh. 25 - Prob. 1MCh. 25 - Prob. 1TFCh. 25 - _________ All infections of polio are crippling.Ch. 25 - Prob. 3TFCh. 25 - Prob. 4TFCh. 25 - Prob. 5TFCh. 25 - Label the steps in retroviral replication shown...Ch. 25 - Prob. 2VICh. 25 - Prob. 1SACh. 25 - Prob. 2SACh. 25 - Prob. 3SACh. 25 - Prob. 4SACh. 25 - Prob. 5SACh. 25 - Prob. 6SACh. 25 - Prob. 8SACh. 25 - Prob. 9SACh. 25 - Prob. 10SACh. 25 - Prob. 11SACh. 25 - Prob. 1CTCh. 25 - A 20-year-old man is brought to a South Carolina...Ch. 25 - Prob. 3CTCh. 25 - Prob. 4CTCh. 25 - Prob. 5CTCh. 25 - Reverse transcriptase is notoriously sloppy in...
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