The two enzymes that is necessary to detoxify the ammonium ion in the presence of pyruvate and the product formed has to be identified. Concept introduction: Transamination of amino acid is the reaction in which amino group is converted to keto acid and formation of a new amino acid takes place. The reaction is the interchange of amino group from given amino acid with the keto group from α-ketoglutarate . During transamination reaction α-ketoglutarate gives glutamate as the product. The product from the amino acid is the keto group. Oxidative deamination is the removal of − N H 4 + bonded to α − c a r b o n and replacing them by a C = O gives the desired α-keto acid . Hyperammonemia is a disease caused as a result of excess of − N H 4 + in the blood.

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Chapter 25, Problem 25.13UKC

Interpretation Introduction

Interpretation:

The two enzymes that is necessary to detoxify the ammonium ion in the presence of pyruvate and the product formed has to be identified.

Concept introduction:

Transamination of amino acid is the reaction in which amino group is converted to keto acid and formation of a new amino acid takes place.

The reaction is the interchange of amino group from given amino acid with the keto group from α-ketoglutarate. During transamination reaction α-ketoglutarate gives glutamate as the product. The product from the amino acid is the keto group.

Oxidative deamination is the removal of −NH4+ bonded to α−carbon and replacing them by a C=O gives the desired α-keto acid.

Hyperammonemia is a disease caused as a result of excess of −NH4+ in the blood.

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