The reason behind the protein cannot remove an alkyl group that attached to guanine. Concept introduction: O 6 -alkylguanine-DNA alkyltransferase is an enzyme that is encoded by the MGMT gene in humans. O 6 -methylguanine is a naturally mutagenic substance. O 6 -alkylguanine-DNA alkyltransferase coverts these harmful substances back to guanine base and also help to repairing the errors in the replication. A closely resembling protein is produced by yeast and some other organism, but the enzyme lacks a Cys at the active site.

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Chapter 25, Problem 21E

(a)

Summary Introduction

To explain: The reason behind the protein cannot remove an alkyl group that attached to guanine.

Concept introduction: O⁶-alkylguanine-DNA alkyltransferase is an enzyme that is encoded by the MGMT gene in humans. O⁶-methylguanine is a naturally mutagenic substance. O⁶-alkylguanine-DNA alkyltransferase coverts these harmful substances back to guanine base and also help to repairing the errors in the replication. A closely resembling protein is produced by yeast and some other organism, but the enzyme lacks a Cys at the active site.

(b)

Summary Introduction

To determine: The type of repair process to which these proteins most likely to participate.

Concept introduction: O⁶-alkylguanine-DNA alkyltransferase is an enzyme that is encoded by the MGMT gene in humans. O⁶-methylguanine is a naturally mutagenic substance. O⁶-alkylguanine-DNA alkyltransferase coverts these harmful substances back to guanine and also help to repair the errors in the replication. A closely resembling protein is produced by yeast and some other organism, but the enzyme lacks a Cys at the active site.

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