BIOLOGY CONNECT ACCESS CODE
3rd Edition
ISBN: 9781259758324
Author: Hoefnagels
Publisher: MCG
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Chapter 24.5, Problem 4MC
Summary Introduction
To determine:
The opposing effects of the parasympathetic and sympathetic nervous systems with the help of examples.
Introduction:
The motor divisions of the peripheral nervous system consist of the somatic nervous system, which carries signals from the brain to the voluntary skeletal muscles and the autonomic nervous system, which carries impulses from the brain to the smooth muscles, cardiac muscles, or glands.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 24 Solutions
BIOLOGY CONNECT ACCESS CODE
Ch. 24.1 - Prob. 1MCCh. 24.1 - Prob. 2MCCh. 24.1 - Distinguish between the central and peripheral...Ch. 24.2 - Describe the parts of a typical neuron.Ch. 24.2 - Prob. 2MCCh. 24.2 - Prob. 3MCCh. 24.3 - Prob. 1MCCh. 24.3 - How does an axon generate and transmit a neural...Ch. 24.3 - Prob. 3MCCh. 24.4 - Describe the structure of a synapse.
Ch. 24.4 - Prob. 2MCCh. 24.4 - Prob. 3MCCh. 24.5 - Prob. 1MCCh. 24.5 - How do the sensory and motor pathways of the...Ch. 24.5 - Prob. 3MCCh. 24.5 - Prob. 4MCCh. 24.6 - Prob. 1MCCh. 24.6 - What are the major structures in the hindbrain,...Ch. 24.6 - Prob. 3MCCh. 24.6 - Prob. 4MCCh. 24.6 - Prob. 5MCCh. 24.7 - Prob. 1MCCh. 24.7 - Prob. 2MCCh. 24.7 - What are the major types of sensory receptors?Ch. 24.7 - Prob. 4MCCh. 24.7 - What is sensory adaptation, and how is it...Ch. 24.8 - Prob. 1MCCh. 24.8 - Prob. 2MCCh. 24.9 - Prob. 1MCCh. 24.9 - Prob. 2MCCh. 24.9 - Prob. 3MCCh. 24.10 - Prob. 1MCCh. 24.10 - Prob. 2MCCh. 24.10 - Prob. 3MCCh. 24.11 - What is the role of mechanoreceptors in the sense...Ch. 24.11 - Prob. 2MCCh. 24 - Prob. 1MCQCh. 24 - Prob. 2MCQCh. 24 - Prob. 3MCQCh. 24 - Prob. 4MCQCh. 24 - Prob. 5MCQCh. 24 - In what way are the senses of smell and taste...Ch. 24 - Prob. 1WIOCh. 24 - Prob. 2WIOCh. 24 - Prob. 3WIOCh. 24 - Prob. 4WIOCh. 24 - How does myelin alter the conduction of a neural...Ch. 24 - Prob. 6WIOCh. 24 - Prob. 7WIOCh. 24 - Prob. 8WIOCh. 24 - Prob. 9WIOCh. 24 - Prob. 10WIOCh. 24 - Prob. 1SLCh. 24 - Prob. 1PITCh. 24 - Prob. 2PITCh. 24 - Prob. 3PIT
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