Student Worksheets For Visual Anatomy & Physiology
3rd Edition
ISBN: 9780134486499
Author: Martini, Frederic H., Ober, William C., Nath, Judi L., Bartholomew, Edwin F., Petti, Kevin
Publisher: PEARSON
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Chapter 24.2, Problem 6R
Summary Introduction
To explain: The reason due to which blood pressure is higher in glomerular capillaries than in other systemic capillaries.
Introduction: The process of filtration is done exclusively in the renal corpuscle, across the filtration membrane. The renal corpuscle mainly has two parts: the glomerulus and the Bowman’s capsule.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 24 Solutions
Student Worksheets For Visual Anatomy & Physiology
Ch. 24.1 - Prob. 1RCh. 24.1 - Prob. 2RCh. 24.1 - Prob. 3RCh. 24.1 - Prob. 4RCh. 24.1 - Prob. 5RCh. 24.1 - Prob. 6RCh. 24.1 - Prob. 7RCh. 24.1 - Prob. 8RCh. 24.1 - Prob. 9RCh. 24.1 - Prob. 10R
Ch. 24.1 - Prob. 11RCh. 24.1 - Prob. 12RCh. 24.1 - Prob. 13RCh. 24.1 - Prob. 1LOCh. 24.1 - Prob. 2LOCh. 24.1 - Prob. 3LOCh. 24.1 - Prob. 4LOCh. 24.1 - Trace the pathway of blood flow through a kidney,...Ch. 24.1 - Prob. 1ICh. 24.1 - Prob. 1SRCh. 24.1 - Prob. 11SRCh. 24.1 - Prob. 12SRCh. 24.1 - Prob. 13SRCh. 24.1 - Prob. 14SRCh. 24.1 - Prob. 15SRCh. 24.1 - Prob. 16SRCh. 24.1 - Prob. 17SRCh. 24.1 - Prob. 18SRCh. 24.1 - Prob. 19SRCh. 24.1 - Short answer: Label the kidney structures in the...Ch. 24.1 - Prob. 21SRCh. 24.1 - Prob. 22SRCh. 24.1 - Prob. 23SRCh. 24.2 - Prob. 1RCh. 24.2 - Prob. 2RCh. 24.2 - Prob. 3RCh. 24.2 - Prob. 4RCh. 24.2 - Prob. 5RCh. 24.2 - Prob. 6RCh. 24.2 - Prob. 7RCh. 24.2 - Prob. 8RCh. 24.2 - Prob. 9RCh. 24.2 - Prob. 10RCh. 24.2 - Prob. 11RCh. 24.2 - Prob. 12RCh. 24.2 - Prob. 13RCh. 24.2 - Prob. 14RCh. 24.2 - Prob. 15RCh. 24.2 - Prob. 16RCh. 24.2 - Prob. 17RCh. 24.2 - Prob. 18RCh. 24.2 - Prob. 1LOCh. 24.2 - Prob. 2LOCh. 24.2 - Prob. 3LOCh. 24.2 - Prob. 4LOCh. 24.2 - Prob. 5LOCh. 24.2 - Prob. 6LOCh. 24.2 - Prob. 7LOCh. 24.2 - Summarize the major steps involved in water...Ch. 24.2 - Compare and contrast chronic and acute renal...Ch. 24.2 - Prob. 1ICh. 24.2 - Prob. 2ICh. 24.2 - Prob. 3ICh. 24.2 - Prob. 4ICh. 24.2 - Prob. 5ICh. 24.2 - Prob. 1SRCh. 24.2 - Matching: Match each lettered term with the most...Ch. 24.2 - Prob. 3SRCh. 24.2 - Prob. 4SRCh. 24.2 - Prob. 5SRCh. 24.2 - Prob. 6SRCh. 24.2 - Prob. 7SRCh. 24.2 - Prob. 8SRCh. 24.2 - Prob. 9SRCh. 24.2 - Prob. 10SRCh. 24.2 - Prob. 11SRCh. 24.2 - Prob. 19SRCh. 24.3 - Prob. 1RCh. 24.3 - Prob. 2RCh. 24.3 - Prob. 3RCh. 24.3 - Prob. 4RCh. 24.3 - Prob. 5RCh. 24.3 - Prob. 6RCh. 24.3 - Prob. 7RCh. 24.3 - Prob. 8RCh. 24.3 - Prob. 1LOCh. 24.3 - Prob. 2LOCh. 24.3 - Prob. 3LOCh. 24.3 - Prob. 4LOCh. 24.3 - Prob. 1ICh. 24.3 - Prob. 1SRCh. 24.3 - Prob. 2SRCh. 24.3 - Prob. 3SRCh. 24.3 - Prob. 4SRCh. 24.3 - Prob. 5SRCh. 24.3 - Prob. 6SRCh. 24.3 - Prob. 7SRCh. 24.3 - Prob. 8SRCh. 24.3 - Matching: Match each lettered term with the most...Ch. 24.3 - Prob. 10SRCh. 24.3 - Prob. 11SRCh. 24.3 - Prob. 12SRCh. 24.3 - Prob. 13SRCh. 24.3 - Prob. 14SRCh. 24.3 - Prob. 15SRCh. 24.3 - Prob. 16SRCh. 24.3 - Prob. 17SRCh. 24.3 - Prob. 18SRCh. 24.3 - Prob. 19SRCh. 24.3 - Short answer: List four primary signs and symptoms...Ch. 24.3 - Briefly describe the similarities and differences...Ch. 24.3 - Prob. 22SRCh. 24.3 - Briefly describe the similarities and differences...Ch. 24 - Prob. 1CRQCh. 24 - Prob. 2CRQCh. 24 - Prob. 3CRQCh. 24 - Prob. 4CRQCh. 24 - Prob. 5CRQCh. 24 - Prob. 6CRQCh. 24 - Prob. 7CRQCh. 24 - Prob. 8CRQCh. 24 - Prob. 9CRQCh. 24 - Prob. 10CRQCh. 24 - Prob. 11CRQCh. 24 - Prob. 12CRQCh. 24 - Prob. 13CRQCh. 24 - Prob. 14CRQCh. 24 - Prob. 15CRQCh. 24 - Prob. 16CRQCh. 24 - Prob. 17CRQCh. 24 - Prob. 18CRQCh. 24 - Water reabsorption occurs primarily along...Ch. 24 - Prob. 20CRQCh. 24 - Prob. 21CRQCh. 24 - Prob. 22CRQCh. 24 - Prob. 23CRQCh. 24 - Prob. 24CRQCh. 24 - Prob. 25CRQCh. 24 - Prob. 1CICh. 24 - Prob. 2CI
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