ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
4th Edition
ISBN: 9781266364051
Author: McKinley
Publisher: MCG
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Textbook Question
Chapter 24.1, Problem 1WDYL
Which structure of the urinary system forms urine, and which structure stores urine?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 24 Solutions
ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
Ch. 24.1 - Which structure of the urinary system forms urine,...Ch. 24.1 - What are the two means by which the kidney helps...Ch. 24.2 - What tissue composes the fibrous capsule that...Ch. 24.2 - What are the regions of the kidney that drain...Ch. 24.2 - What three anatomic structures of the kidney are...Ch. 24.3 - Prob. 6WDYLCh. 24.3 - Prob. 7WDYLCh. 24.3 - Prob. 8WDYLCh. 24.3 - Differentiate between the function of principal...Ch. 24.3 - What are the two primary cellular components of...
Ch. 24.4 - Prob. 11WDYLCh. 24.4 - What are the three major types of capillaries...Ch. 24.4 - What is the pathway of fluid filtered by the...Ch. 24.5 - How does tubular reabsorption differ from tubular...Ch. 24.5 - How are the components of the filtration membrane...Ch. 24.5 - What is normally filtered across the glomerular...Ch. 24.5 - Prob. 17WDYLCh. 24.5 - What is the value of the NFP if the glomerular...Ch. 24.5 - Prob. 19WDYLCh. 24.5 - If HPg increases, what is the effect on NFP? Is...Ch. 24.5 - Does urine production increase, decrease, or stay...Ch. 24.5 - What are the three factors that regulate...Ch. 24.5 - Prob. 23WDYLCh. 24.6 - What are the significant anatomic and physiologic...Ch. 24.6 - What is the transport maximum of a substance? How...Ch. 24.6 - Prob. 26WDYLCh. 24.6 - Why are proteins said to be transported rather...Ch. 24.6 - How does Na+ reabsorption occur? Which two...Ch. 24.6 - What is the effect of parathyroid hormone on the...Ch. 24.6 - How is the movement of H+ and HCO3 regulated by...Ch. 24.6 - Prob. 31WDYLCh. 24.6 - Prob. 32WDYLCh. 24.6 - Prob. 33WDYLCh. 24.7 - Prob. 34WDYLCh. 24.7 - Prob. 35WDYLCh. 24.8 - Prob. 36WDYLCh. 24.8 - Prob. 37WDYLCh. 24.8 - Prob. 38WDYLCh. 24.8 - Prob. 39WDYLCh. 24 - Prob. 1DYKBCh. 24 - _____ 2. When the kidneys are described as being...Ch. 24 - _____ 3. Which of the following is located within...Ch. 24 - _____ 4. All of the following are capillaries...Ch. 24 - _____ 5. Which of the following is a component of...Ch. 24 - _____ 6. If blood pressure in the glomerulus...Ch. 24 - _____ 7. Which hormone increases Na+ and water...Ch. 24 - _____ 8. If the tubular maximum is exceeded, then...Ch. 24 - _____ 9. The function unique to the nephron loop...Ch. 24 - _____ 10. If antidiuretic hormone (ADH)...Ch. 24 - Trace blood flow into and out of the kidney....Ch. 24 - Describe where filtrate, tubular fluid, and urine...Ch. 24 - Describe the anatomic components of the...Ch. 24 - Prob. 14DYKBCh. 24 - Explain how glomerular filtration rate (GFR) is...Ch. 24 - Discuss the affect of aldosterone and antidiuretic...Ch. 24 - Explain how antidiuretic hormone (ADH) is...Ch. 24 - Describe the significant differences between blood...Ch. 24 - Identify all of the following that are functions...Ch. 24 - Explain the process of micturition.Ch. 24 - Use the following paragraph to answer questions...Ch. 24 - Prob. 2CALCh. 24 - Use the following paragraph to answer questions...Ch. 24 - Martin, a young man of 20, was in a car accident...Ch. 24 - A 19-year-old male named Paul was in a diving...Ch. 24 - A patient with cancer is treated with...Ch. 24 - Prob. 2CSLCh. 24 - Males who suffer from either benign prostatic...
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