17th Edition

ISBN: 9781630180928

Author: OpenStax

Publisher: OPENSTAX C

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We are involved in several daily activities. These actions need a significant quantity of energy. The food we eat provides this energy. Food is necessary for development, repair, and other living activities since it supplies energy. All of these are part…

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Chapter 24, Problem 41CTQ

How can the ingestion of food increase the body temperature?

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Chapter 24, Problem 40CTQ

Chapter 24, Problem 42CTQ

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…

The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?

Chapter 24 Solutions

ANATOMY AND PHYSIOLOGY

Ch. 24 - A monosaccharide is formed from a polysaccharide...Ch. 24 - If anabolic reactions exceed catabolic reactions,...Ch. 24 - When NAD becomes NADH, the coenzyme has been...Ch. 24 - Anabolic reactions use energy by ________. turning...Ch. 24 - Glycolysis results in the production of two...Ch. 24 - The Krebs cycle converts ________ through a cycle...Ch. 24 - Which pathway produces the most ATP molecules?...Ch. 24 - Aerobic cellular respiration results in the...Ch. 24 - When NAD+ becomes NADH, the coenzyme has been...Ch. 24 - Lipids in the diet can be ________. broken down...

Ch. 24 - The gallbladder provides ________ that aid(s) in...Ch. 24 - Triglycerides are transported by chylomicrons...Ch. 24 - Which molecule produces the most ATP?...Ch. 24 - Which molecules can enter the Krebs cycle?...Ch. 24 - Acetyl CoA can be converted to all of the...Ch. 24 - Digestion of proteins begins in the ________ where...Ch. 24 - Amino acids are needed to ________. build new...Ch. 24 - If an amino acid is not used to create new...Ch. 24 - During the absorptive state, glucose levels are...Ch. 24 - Staivation sets in after 3 to 4 days without food....Ch. 24 - The postabsorptive state relies on stores of...Ch. 24 - The bodys temperature is controlled by the...Ch. 24 - Fever increases the body temperature and can...Ch. 24 - The heat you feel on your chair when you stand up...Ch. 24 - A crowded room warms up through the mechanism of...Ch. 24 - A deficiency in vitamin A can result in ________....Ch. 24 - Rickets results in improper bone development in...Ch. 24 - Consuming which type of food will help the most...Ch. 24 - Which of the following is stored in the body?...Ch. 24 - Describe how metabolism can be altered.Ch. 24 - Describe how Addisons disease can be treated.Ch. 24 - Explain how glucose is metabolized to yield ATP.Ch. 24 - Insulin is released when food is ingested and...Ch. 24 - Discuss how carbohydrates can be stored as fat.Ch. 24 - If a diabetics breath smeLls like alcohol, what...Ch. 24 - Amino acids are not stored in the body. Describe...Ch. 24 - Release of trypsin and chymotrypsin in their...Ch. 24 - In type II diabetes, insulin is produced but is...Ch. 24 - Ketone bodies are used as an alternative source of...Ch. 24 - How does vasoconstriction help increase the core...Ch. 24 - How can the ingestion of food increase the body...Ch. 24 - Weight loss and weight gain are complex processes....Ch. 24 - Some low-fat or non-fat foods contain a large...

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