ORGANIC CHEMISTRY
ORGANIC CHEMISTRY
9th Edition
ISBN: 9780134645704
Author: WADE AND SIMEK
Publisher: PEARSON
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Chapter 24, Problem 24.45SP

(a)

Interpretation Introduction

To determine: The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester.

Interpretation: The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester is to be stated.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

(b)

Interpretation Introduction

To determine: The mechanism for the given reaction that coverts an acid to NHS ester.

Interpretation: The mechanism for the given reaction that coverts an acid to NHS ester is to be predicted.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

(c)

Interpretation Introduction

To determine: The mechanism for the reaction of NHS ester with an amine, RNH2.

Interpretation: The mechanism for the reaction of NHS ester with an amine, RNH2 is to be predicted.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

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Chapter 24 Solutions

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