The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester. Interpretation: The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester is to be stated. Concept introduction: The compound containing a good leaving group that has molecular formula C 4 H 5 NO 3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

Question

Want to see the full answer?

Answer 1

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 24, Problem 24.45SP

(a)

Interpretation Introduction

To determine: The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester.

Interpretation: The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester is to be stated.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

(b)

Interpretation Introduction

To determine: The mechanism for the given reaction that coverts an acid to NHS ester.

Interpretation: The mechanism for the given reaction that coverts an acid to NHS ester is to be predicted.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

(c)

Interpretation Introduction

To determine: The mechanism for the reaction of NHS ester with an amine, R−NH2.

Interpretation: The mechanism for the reaction of NHS ester with an amine, R−NH2 is to be predicted.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

MISSED THIS? Read Section 19.9 (Pages 878-881); Watch IWE 19.10 Consider the following reaction: CH3OH(g) CO(g) + 2H2(g) (Note that AG,CH3OH(g) = -162.3 kJ/mol and AG,co(g)=-137.2 kJ/mol.) Part A Calculate AG for this reaction at 25 °C under the following conditions: PCH₂OH Pco PH2 0.815 atm = 0.140 atm 0.170 atm Express your answer in kilojoules to three significant figures. Ο ΑΣΦ AG = -150 Submit Previous Answers Request Answer □? kJ × Incorrect; Try Again; 2 attempts remaining Calculate the free energy change under nonstandard conditions (AGrxn) by using the following relationship: AGrxn = AGrxn + RTInQ, AGxn+RTInQ, where AGxn is the standard free energy change, R is the ideal gas constant, T is the temperature in kelvins, a is the reaction quotient. Provide Feedback Next >

Identify and provide a brief explanation of Gas Chromatography (GC) within the context of chemical analysis of food. Incorporate the specific application name, provide a concise overview of sample preparation methods, outline instrumental parameters and conditions ultilized, and summarise the outcomes and findings achieved through this analytical approach.

Identify and provide a concise explanation of the concept of signal-to-noise ratio (SNR) in the context of chemical analysis. Provide specific examples.

Answer 2

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 24, Problem 24.45SP

(a)

Interpretation Introduction

To determine: The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester.

Interpretation: The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester is to be stated.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

(b)

Interpretation Introduction

To determine: The mechanism for the given reaction that coverts an acid to NHS ester.

Interpretation: The mechanism for the given reaction that coverts an acid to NHS ester is to be predicted.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

(c)

Interpretation Introduction

To determine: The mechanism for the reaction of NHS ester with an amine, R−NH2.

Interpretation: The mechanism for the reaction of NHS ester with an amine, R−NH2 is to be predicted.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 3

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 24, Problem 24.45SP

(a)

Interpretation Introduction

To determine: The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester.

Interpretation: The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester is to be stated.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

(b)

Interpretation Introduction

To determine: The mechanism for the given reaction that coverts an acid to NHS ester.

Interpretation: The mechanism for the given reaction that coverts an acid to NHS ester is to be predicted.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

(c)

Interpretation Introduction

To determine: The mechanism for the reaction of NHS ester with an amine, R−NH2.

Interpretation: The mechanism for the reaction of NHS ester with an amine, R−NH2 is to be predicted.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 24, Problem 24.45SP

(a)

Interpretation Introduction

To determine: The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester.

Interpretation: The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester is to be stated.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

(b)

Interpretation Introduction

To determine: The mechanism for the given reaction that coverts an acid to NHS ester.

Interpretation: The mechanism for the given reaction that coverts an acid to NHS ester is to be predicted.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

(c)

Interpretation Introduction

To determine: The mechanism for the reaction of NHS ester with an amine, R−NH2.

Interpretation: The mechanism for the reaction of NHS ester with an amine, R−NH2 is to be predicted.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 5

Chapter 24, Problem 24.45SP

(a)

Interpretation Introduction

To determine: The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester.

Interpretation: The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester is to be stated.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

(b)

Interpretation Introduction

To determine: The mechanism for the given reaction that coverts an acid to NHS ester.

Interpretation: The mechanism for the given reaction that coverts an acid to NHS ester is to be predicted.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

(c)

Interpretation Introduction

To determine: The mechanism for the reaction of NHS ester with an amine, R−NH2.

Interpretation: The mechanism for the reaction of NHS ester with an amine, R−NH2 is to be predicted.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

Answer 6

Chapter 24, Problem 24.45SP

(a)

Interpretation Introduction

To determine: The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester.

Interpretation: The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester is to be stated.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

Answer 7

Chapter 24, Problem 24.45SP

(a)

Interpretation Introduction

To determine: The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester.

Interpretation: The reason corresponding to the fact that an NHS ester is much more reactive than a simple alkyl ester is to be stated.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

Answer 8

(b)

Interpretation Introduction

To determine: The mechanism for the given reaction that coverts an acid to NHS ester.

Interpretation: The mechanism for the given reaction that coverts an acid to NHS ester is to be predicted.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

Answer 9

(b)

Interpretation Introduction

To determine: The mechanism for the given reaction that coverts an acid to NHS ester.

Interpretation: The mechanism for the given reaction that coverts an acid to NHS ester is to be predicted.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

Answer 10

(c)

Interpretation Introduction

To determine: The mechanism for the reaction of NHS ester with an amine, R−NH2.

Interpretation: The mechanism for the reaction of NHS ester with an amine, R−NH2 is to be predicted.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

Answer 11

(c)

Interpretation Introduction

To determine: The mechanism for the reaction of NHS ester with an amine, R−NH2.

Interpretation: The mechanism for the reaction of NHS ester with an amine, R−NH2 is to be predicted.

Concept introduction: The compound containing a good leaving group that has molecular formula C4H5NO3 and is used as an activating reagent for carboxylic acid is known as N-hydroxysuccinimide (NHS). It is slightly acidic in nature.

Answer 12

Expert Solution & Answer

Answer 13

Expert Solution & Answer

Answer 14

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 15

Ch. 24.2A - Draw three-dimensional representations of the...Ch. 24.2A - Prob. 24.2P Ch. 24.2B - The herbicide glyphosate (Roundup) kills plants by...Ch. 24.4 - Draw the structure of the predominant form of a....Ch. 24.4 - Draw the resonance forms of a protonated guanidino...Ch. 24.4 - Although tryptophan contains a heterocyclic amine,...Ch. 24.4 - Prob. 24.7P Ch. 24.4 - Prob. 24.8P Ch. 24.5A - Show how the following amino acids might be formed...Ch. 24.5B - Prob. 24.10P

Concept explainers

Want to see the full answer?

Chapter 24 Solutions