The ways by which the potential to differentiate leukemic cells from healthy cells provides an opportunity to develop a therapy for CML treatment. Introduction: In the case of CML (chronic myelogenous leukemia), leukemic cells can be distinguished from healthy body cells. This difference occurs due to the presence of functional BCR-ABL hybrid protein.

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Answer 1

Question

Chapter 24, Problem 1NST

Summary Introduction

To determine: The ways by which the potential to differentiate leukemic cells from healthy cells provides an opportunity to develop a therapy for CML treatment.

Introduction: In the case of CML (chronic myelogenous leukemia), leukemic cells can be distinguished from healthy body cells. This difference occurs due to the presence of functional BCR-ABL hybrid protein.

Expert Solution & Answer

Explanation of Solution

One of the approaches that can be utilized to fight CML includes the use of tyrosine kinase inhibitor. This inhibitor binds to the ATP binding site of ABL kinase by inhibiting BCR-ABL phosphorylation and preventing the activation signaling pathways.

Moreover, real-time Q-RT-PCR (quantitative reverse transcription-polymerase chain reaction) allows an individual to monitor drug responses of cell populations in the patient. This approach is used to develop less toxic and effective treatments.

The potential to differentiate leukemic cells from normal cells allows an individual not to target therapy to specific cell populations but also to quantify responses to therapy. The leukemic cells produce an unusual hybrid protein known as BCR-ABL. Therefore, it may be possible to develop a therapy such as immunotherapy, based on the uniqueness of BCR-ABL protein.

Conclusion

Thus, the uniqueness of BCR-ABL protein may be used to develop immunotherapy for CML treatment.

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Answer 2

Question

Chapter 24, Problem 1NST

Summary Introduction

To determine: The ways by which the potential to differentiate leukemic cells from healthy cells provides an opportunity to develop a therapy for CML treatment.

Introduction: In the case of CML (chronic myelogenous leukemia), leukemic cells can be distinguished from healthy body cells. This difference occurs due to the presence of functional BCR-ABL hybrid protein.

Expert Solution & Answer

Explanation of Solution

One of the approaches that can be utilized to fight CML includes the use of tyrosine kinase inhibitor. This inhibitor binds to the ATP binding site of ABL kinase by inhibiting BCR-ABL phosphorylation and preventing the activation signaling pathways.

Moreover, real-time Q-RT-PCR (quantitative reverse transcription-polymerase chain reaction) allows an individual to monitor drug responses of cell populations in the patient. This approach is used to develop less toxic and effective treatments.

The potential to differentiate leukemic cells from normal cells allows an individual not to target therapy to specific cell populations but also to quantify responses to therapy. The leukemic cells produce an unusual hybrid protein known as BCR-ABL. Therefore, it may be possible to develop a therapy such as immunotherapy, based on the uniqueness of BCR-ABL protein.

Conclusion

Thus, the uniqueness of BCR-ABL protein may be used to develop immunotherapy for CML treatment.

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Answer 3

Question

Chapter 24, Problem 1NST

Summary Introduction

To determine: The ways by which the potential to differentiate leukemic cells from healthy cells provides an opportunity to develop a therapy for CML treatment.

Introduction: In the case of CML (chronic myelogenous leukemia), leukemic cells can be distinguished from healthy body cells. This difference occurs due to the presence of functional BCR-ABL hybrid protein.

Expert Solution & Answer

Explanation of Solution

One of the approaches that can be utilized to fight CML includes the use of tyrosine kinase inhibitor. This inhibitor binds to the ATP binding site of ABL kinase by inhibiting BCR-ABL phosphorylation and preventing the activation signaling pathways.

Moreover, real-time Q-RT-PCR (quantitative reverse transcription-polymerase chain reaction) allows an individual to monitor drug responses of cell populations in the patient. This approach is used to develop less toxic and effective treatments.

The potential to differentiate leukemic cells from normal cells allows an individual not to target therapy to specific cell populations but also to quantify responses to therapy. The leukemic cells produce an unusual hybrid protein known as BCR-ABL. Therefore, it may be possible to develop a therapy such as immunotherapy, based on the uniqueness of BCR-ABL protein.

Conclusion

Thus, the uniqueness of BCR-ABL protein may be used to develop immunotherapy for CML treatment.

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Answer 4

Question

Chapter 24, Problem 1NST

Summary Introduction

To determine: The ways by which the potential to differentiate leukemic cells from healthy cells provides an opportunity to develop a therapy for CML treatment.

Introduction: In the case of CML (chronic myelogenous leukemia), leukemic cells can be distinguished from healthy body cells. This difference occurs due to the presence of functional BCR-ABL hybrid protein.

Expert Solution & Answer

Explanation of Solution

One of the approaches that can be utilized to fight CML includes the use of tyrosine kinase inhibitor. This inhibitor binds to the ATP binding site of ABL kinase by inhibiting BCR-ABL phosphorylation and preventing the activation signaling pathways.

Moreover, real-time Q-RT-PCR (quantitative reverse transcription-polymerase chain reaction) allows an individual to monitor drug responses of cell populations in the patient. This approach is used to develop less toxic and effective treatments.

The potential to differentiate leukemic cells from normal cells allows an individual not to target therapy to specific cell populations but also to quantify responses to therapy. The leukemic cells produce an unusual hybrid protein known as BCR-ABL. Therefore, it may be possible to develop a therapy such as immunotherapy, based on the uniqueness of BCR-ABL protein.

Conclusion

Thus, the uniqueness of BCR-ABL protein may be used to develop immunotherapy for CML treatment.

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Answer 5

Chapter 24, Problem 1NST

Summary Introduction

To determine: The ways by which the potential to differentiate leukemic cells from healthy cells provides an opportunity to develop a therapy for CML treatment.

Introduction: In the case of CML (chronic myelogenous leukemia), leukemic cells can be distinguished from healthy body cells. This difference occurs due to the presence of functional BCR-ABL hybrid protein.

Expert Solution & Answer

Explanation of Solution

One of the approaches that can be utilized to fight CML includes the use of tyrosine kinase inhibitor. This inhibitor binds to the ATP binding site of ABL kinase by inhibiting BCR-ABL phosphorylation and preventing the activation signaling pathways.

Moreover, real-time Q-RT-PCR (quantitative reverse transcription-polymerase chain reaction) allows an individual to monitor drug responses of cell populations in the patient. This approach is used to develop less toxic and effective treatments.

The potential to differentiate leukemic cells from normal cells allows an individual not to target therapy to specific cell populations but also to quantify responses to therapy. The leukemic cells produce an unusual hybrid protein known as BCR-ABL. Therefore, it may be possible to develop a therapy such as immunotherapy, based on the uniqueness of BCR-ABL protein.

Conclusion

Thus, the uniqueness of BCR-ABL protein may be used to develop immunotherapy for CML treatment.

Answer 6

Chapter 24, Problem 1NST

Summary Introduction

To determine: The ways by which the potential to differentiate leukemic cells from healthy cells provides an opportunity to develop a therapy for CML treatment.

Introduction: In the case of CML (chronic myelogenous leukemia), leukemic cells can be distinguished from healthy body cells. This difference occurs due to the presence of functional BCR-ABL hybrid protein.

Expert Solution & Answer

Explanation of Solution

One of the approaches that can be utilized to fight CML includes the use of tyrosine kinase inhibitor. This inhibitor binds to the ATP binding site of ABL kinase by inhibiting BCR-ABL phosphorylation and preventing the activation signaling pathways.

Moreover, real-time Q-RT-PCR (quantitative reverse transcription-polymerase chain reaction) allows an individual to monitor drug responses of cell populations in the patient. This approach is used to develop less toxic and effective treatments.

The potential to differentiate leukemic cells from normal cells allows an individual not to target therapy to specific cell populations but also to quantify responses to therapy. The leukemic cells produce an unusual hybrid protein known as BCR-ABL. Therefore, it may be possible to develop a therapy such as immunotherapy, based on the uniqueness of BCR-ABL protein.

Conclusion

Thus, the uniqueness of BCR-ABL protein may be used to develop immunotherapy for CML treatment.

Answer 7

Chapter 24, Problem 1NST

Summary Introduction

To determine: The ways by which the potential to differentiate leukemic cells from healthy cells provides an opportunity to develop a therapy for CML treatment.

Introduction: In the case of CML (chronic myelogenous leukemia), leukemic cells can be distinguished from healthy body cells. This difference occurs due to the presence of functional BCR-ABL hybrid protein.

Answer 8

Expert Solution & Answer

Explanation of Solution

One of the approaches that can be utilized to fight CML includes the use of tyrosine kinase inhibitor. This inhibitor binds to the ATP binding site of ABL kinase by inhibiting BCR-ABL phosphorylation and preventing the activation signaling pathways.

Moreover, real-time Q-RT-PCR (quantitative reverse transcription-polymerase chain reaction) allows an individual to monitor drug responses of cell populations in the patient. This approach is used to develop less toxic and effective treatments.

The potential to differentiate leukemic cells from normal cells allows an individual not to target therapy to specific cell populations but also to quantify responses to therapy. The leukemic cells produce an unusual hybrid protein known as BCR-ABL. Therefore, it may be possible to develop a therapy such as immunotherapy, based on the uniqueness of BCR-ABL protein.

Answer 9

Expert Solution & Answer

Answer 10

Expert Solution & Answer

Answer 11

Conclusion

Thus, the uniqueness of BCR-ABL protein may be used to develop immunotherapy for CML treatment.

Answer 12

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