Anatomy & Physiology: The Unity of Form and Function (Standalone Book)
7th Edition
ISBN: 9780073403717
Author: Kenneth S. Saladin Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 24, Problem 16TYR
An excessive concentration of potassium ions in the blood is called ________.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 24 Solutions
Anatomy & Physiology: The Unity of Form and Function (Standalone Book)
Ch. 24.1 - Prob. 1BYGOCh. 24.1 - Prob. 2BYGOCh. 24.1 - Prob. 3BYGOCh. 24.1 - Prob. 4BYGOCh. 24.1 - Prob. 5BYGOCh. 24.1 - Prob. 1AYLOCh. 24.1 - Prob. 2AYLOCh. 24.1 - Prob. 3AYLOCh. 24.1 - Prob. 4AYLOCh. 24.1 - Prob. 5AYLO
Ch. 24.1 - Prob. 6AYLOCh. 24.1 - Prob. 7AYLOCh. 24.1 - Prob. 8AYLOCh. 24.1 - Prob. 9AYLOCh. 24.1 - Prob. 10AYLOCh. 24.1 - Prob. 11AYLOCh. 24.2 - Prob. 6BYGOCh. 24.2 - Prob. 7BYGOCh. 24.2 - Prob. 8BYGOCh. 24.2 - Prob. 9BYGOCh. 24.2 - Prob. 10BYGOCh. 24.2 - Prob. 11BYGOCh. 24.2 - Prob. 1AYLOCh. 24.2 - Prob. 2AYLOCh. 24.2 - Prob. 3AYLOCh. 24.2 - Prob. 4AYLOCh. 24.2 - Prob. 5AYLOCh. 24.2 - Prob. 6AYLOCh. 24.2 - Prob. 7AYLOCh. 24.3 - Prob. 12BYGOCh. 24.3 - Prob. 13BYGOCh. 24.3 - Prob. 14BYGOCh. 24.3 - Prob. 15BYGOCh. 24.3 - Prob. 1AYLOCh. 24.3 - Prob. 2AYLOCh. 24.3 - Prob. 3AYLOCh. 24.3 - Prob. 4AYLOCh. 24.3 - Prob. 5AYLOCh. 24.3 - Prob. 6AYLOCh. 24.3 - Prob. 7AYLOCh. 24.3 - Prob. 8AYLOCh. 24.3 - Prob. 9AYLOCh. 24.3 - Prob. 10AYLOCh. 24.3 - Prob. 11AYLOCh. 24 - The greatest percentage of the bodys water is in...Ch. 24 - Prob. 2TYRCh. 24 - increases water reabsorption without increasing...Ch. 24 - Prob. 4TYRCh. 24 - Prob. 5TYRCh. 24 - The principal determinant of intracellular...Ch. 24 - Prob. 7TYRCh. 24 - Prob. 8TYRCh. 24 - Prob. 9TYRCh. 24 - Hyperchloremia is most likely to result in a....Ch. 24 - The most abundant cation in the ECF is __________.Ch. 24 - Prob. 12TYRCh. 24 - Water produced by the bodys chemical reactions is...Ch. 24 - Prob. 14TYRCh. 24 - Any abnormal accumulation of fluid in a particular...Ch. 24 - An excessive concentration of potassium ions in...Ch. 24 - Prob. 17TYRCh. 24 - Prob. 18TYRCh. 24 - Prob. 19TYRCh. 24 - Long-term satiation of thirst depends on a...Ch. 24 - Prob. 1BYMVCh. 24 - Prob. 2BYMVCh. 24 - Prob. 3BYMVCh. 24 - Prob. 4BYMVCh. 24 - Prob. 5BYMVCh. 24 - para-Ch. 24 - Prob. 7BYMVCh. 24 - Prob. 8BYMVCh. 24 - Prob. 9BYMVCh. 24 - vol-Ch. 24 - Prob. 1TFCh. 24 - Prob. 2TFCh. 24 - Prob. 3TFCh. 24 - Prob. 4TFCh. 24 - Prob. 5TFCh. 24 - Prob. 6TFCh. 24 - Prob. 7TFCh. 24 - Prob. 8TFCh. 24 - In true dehydration, the body fluids remain...Ch. 24 - Prob. 10TFCh. 24 - Prob. 1TYCCh. 24 - Prob. 2TYCCh. 24 - Prob. 3TYCCh. 24 - Prob. 4TYCCh. 24 - Prob. 5TYC
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