EBK ORGANIC CHEMISTRY
12th Edition
ISBN: 9781119233664
Author: Snyder
Publisher: VST
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Chapter 24, Problem 15PP
Interpretation Introduction
Interpretation:
The explanation of structural features of a linker, which make it possible for the polypeptide to be detached from the Wang resin using trifluoroacetic acid, is to be given.
Concept introduction:
In solid-phase peptide synthesis (SPPS), peptides are prepared, residue by residue. The peptide is attached to
The polypeptide is finally cleaved from the polymer support and is purified by HPLC (high-performance liquid chromatography). The Wang resin is used as polymer support for the batch synthesis of peptide acids following the Fmoc- or tert-Bu-protection. It is cleaved by TFA.
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Indicate the substitutes in one place, if they are a diazonio room.
Indicate the product formed in each reaction. If the
product exhibits tautomerism, draw the tautomeric
structure.
a) о
+ CH3-NH-NH2
CO2C2H5
b)
+ CoH5-NH-NH2
OC2H5
Indicate the formula of the compound, that is the result of the N-
alquilación (nucleofílic substitution), in which an additional lateral
chain was formed (NH-CH2-COOMe).
F3C.
CF3
NH
NH2
Br о
OMe
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Chapter 24 Solutions
EBK ORGANIC CHEMISTRY
Ch. 24 - Prob. 1PPCh. 24 - Practice Problem 24.2 The guanidino group NHNHCNH2...Ch. 24 - Prob. 3PPCh. 24 - Prob. 4PPCh. 24 - Prob. 5PPCh. 24 - Prob. 6PPCh. 24 - Prob. 7PPCh. 24 - Practice Problem 24.8
Glutathione is a tripeptide...Ch. 24 - Prob. 9PPCh. 24 - Prob. 10PP
Ch. 24 - Prob. 11PPCh. 24 - Practice Problem 24.12 Show all steps in the...Ch. 24 - Practice Problem 24.13 The synthesis of a...Ch. 24 - Practice Problem 24.14
The terminal carboxyl...Ch. 24 - Prob. 15PPCh. 24 - Prob. 16PPCh. 24 - (a) Which amino acids in Table 24.1 have more than...Ch. 24 - Prob. 18PCh. 24 - 24.19 (a) On the basis of the following sequence...Ch. 24 - Prob. 20PCh. 24 - Prob. 21PCh. 24 - Prob. 22PCh. 24 - Prob. 23PCh. 24 - Prob. 24PCh. 24 - The enzyme lysozyme and its mechanism are...Ch. 24 - Prob. 2LGP
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