The classes of reactions are involved in the cleavage of the Fmoc group with piperidine, leading to the unprotected amino acid and the fluorene byproduct are to be determined. The mechanisms for these reactions are to be written. Concept introduction: The 9-fluorenylmethyloxycarbonyl protecting group (Fmoc) is a protecting group particularly used in peptide chemistry. It protects the amino group of the first amino acid. It is stable under low pH, but can be removed under high pH. The solution of 20% piperidine in DMF is usually employed.

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Answer 1

Question

Chapter 24, Problem 11PP

Interpretation Introduction

Interpretation:

The classes of reactions are involved in the cleavage of the Fmoc group with piperidine,

leading to the unprotected amino acid and the fluorene byproduct are to be determined. The mechanisms for these reactions are to be written.

Concept introduction:

The 9-fluorenylmethyloxycarbonyl protecting group (Fmoc) is a protecting group particularly used in peptide chemistry. It protects the amino group of the first amino acid. It is stable under low pH, but can be removed under high pH. The solution of 20% piperidine in DMF is usually employed.

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Answer 2

Question

Chapter 24, Problem 11PP

Interpretation Introduction

Interpretation:

The classes of reactions are involved in the cleavage of the Fmoc group with piperidine,

leading to the unprotected amino acid and the fluorene byproduct are to be determined. The mechanisms for these reactions are to be written.

Concept introduction:

The 9-fluorenylmethyloxycarbonyl protecting group (Fmoc) is a protecting group particularly used in peptide chemistry. It protects the amino group of the first amino acid. It is stable under low pH, but can be removed under high pH. The solution of 20% piperidine in DMF is usually employed.

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Answer 3

Question

Chapter 24, Problem 11PP

Interpretation Introduction

Interpretation:

The classes of reactions are involved in the cleavage of the Fmoc group with piperidine,

leading to the unprotected amino acid and the fluorene byproduct are to be determined. The mechanisms for these reactions are to be written.

Concept introduction:

The 9-fluorenylmethyloxycarbonyl protecting group (Fmoc) is a protecting group particularly used in peptide chemistry. It protects the amino group of the first amino acid. It is stable under low pH, but can be removed under high pH. The solution of 20% piperidine in DMF is usually employed.

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Answer 4

Question

Chapter 24, Problem 11PP

Interpretation Introduction

Interpretation:

The classes of reactions are involved in the cleavage of the Fmoc group with piperidine,

leading to the unprotected amino acid and the fluorene byproduct are to be determined. The mechanisms for these reactions are to be written.

Concept introduction:

The 9-fluorenylmethyloxycarbonyl protecting group (Fmoc) is a protecting group particularly used in peptide chemistry. It protects the amino group of the first amino acid. It is stable under low pH, but can be removed under high pH. The solution of 20% piperidine in DMF is usually employed.

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Answer 5

Chapter 24, Problem 11PP

Interpretation Introduction

Interpretation:

The classes of reactions are involved in the cleavage of the Fmoc group with piperidine,

leading to the unprotected amino acid and the fluorene byproduct are to be determined. The mechanisms for these reactions are to be written.

Concept introduction:

The 9-fluorenylmethyloxycarbonyl protecting group (Fmoc) is a protecting group particularly used in peptide chemistry. It protects the amino group of the first amino acid. It is stable under low pH, but can be removed under high pH. The solution of 20% piperidine in DMF is usually employed.

Answer 6

Chapter 24, Problem 11PP

Interpretation Introduction

Interpretation:

The classes of reactions are involved in the cleavage of the Fmoc group with piperidine,

leading to the unprotected amino acid and the fluorene byproduct are to be determined. The mechanisms for these reactions are to be written.

Concept introduction:

The 9-fluorenylmethyloxycarbonyl protecting group (Fmoc) is a protecting group particularly used in peptide chemistry. It protects the amino group of the first amino acid. It is stable under low pH, but can be removed under high pH. The solution of 20% piperidine in DMF is usually employed.

Answer 7

Chapter 24, Problem 11PP

Interpretation Introduction

Interpretation:

The classes of reactions are involved in the cleavage of the Fmoc group with piperidine,

leading to the unprotected amino acid and the fluorene byproduct are to be determined. The mechanisms for these reactions are to be written.

Concept introduction:

The 9-fluorenylmethyloxycarbonyl protecting group (Fmoc) is a protecting group particularly used in peptide chemistry. It protects the amino group of the first amino acid. It is stable under low pH, but can be removed under high pH. The solution of 20% piperidine in DMF is usually employed.

Answer 8

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Answer 10

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Answer 11

Ch. 24 - Prob. 1PP Ch. 24 - Practice Problem 24.2 The guanidino group NHNHCNH2...Ch. 24 - Prob. 3PP Ch. 24 - Prob. 4PP Ch. 24 - Prob. 5PP Ch. 24 - Prob. 6PP Ch. 24 - Prob. 7PP Ch. 24 - Practice Problem 24.8 Glutathione is a tripeptide...Ch. 24 - Prob. 9PP Ch. 24 - Prob. 10PP

Solution Summary: The author describes the reactions involved in the cleavage of the Fmoc group with piperidine, leading to the unprotected amino acid and the fluorene byproduct.

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Chapter 24 Solutions