Connect Access for Seeley's Anatomy and Physiology 180 Day Access for LIBERTY UNIVERSITY BIOL 213/215
11th Edition
ISBN: 9781259987304
Author: VanPutte
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Textbook Question
Chapter 23.6, Problem 52AYP
What is the Bohr effect? How is it related to blood CO2?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 23 Solutions
Connect Access for Seeley's Anatomy and Physiology 180 Day Access for LIBERTY UNIVERSITY BIOL 213/215
Ch. 23.1 - Prob. 1AYPCh. 23.1 - Explain the functions of the respiratory system.Ch. 23.2 - Prob. 3AYPCh. 23.2 - Explain how the conducting zone differs from the...Ch. 23.2 - Describe the structures of the nasal cavity.Ch. 23.2 - Prob. 6AYPCh. 23.2 - Prob. 7AYPCh. 23.2 - Prob. 8AYPCh. 23.2 - Distinguish between the vestibular and vocal...Ch. 23.2 - How does the position of the arytenoid cartilages...
Ch. 23.2 - What are the four functions of the larynx?Ch. 23.2 - Explain the branching of the tracheobronchial...Ch. 23.2 - Describe the arrangement of cartilage, smooth...Ch. 23.2 - How is debris removed from the trocheobronchial...Ch. 23.2 - Name the two types of cells in the alveolar wall,...Ch. 23.2 - Prob. 16AYPCh. 23.2 - Distinguish among a lung, a lung lobe, a...Ch. 23.2 - Prob. 18AYPCh. 23.2 - List the muscles of inspiration, and describe...Ch. 23.2 - Name the pleurae of the lungs. What is their...Ch. 23.2 - What are the two major routes of blood flow to and...Ch. 23.2 - Prob. 22AYPCh. 23.3 - What is ventilation?Ch. 23.3 - How do pressure differences and resistance affect...Ch. 23.3 - Prob. 25AYPCh. 23.3 - Prob. 26AYPCh. 23.3 - Prob. 27AYPCh. 23.3 - Prob. 28AYPCh. 23.3 - Prob. 29AYPCh. 23.3 - Prob. 30AYPCh. 23.3 - Prob. 31AYPCh. 23.3 - Prob. 32AYPCh. 23.3 - Prob. 33AYPCh. 23.4 - Prob. 34AYPCh. 23.4 - Prob. 35AYPCh. 23.4 - Prob. 36AYPCh. 23.4 - Prob. 37AYPCh. 23.4 - Prob. 38AYPCh. 23.4 - What is dead space? Contrast anatomical dead space...Ch. 23.5 - Prob. 40AYPCh. 23.5 - Prob. 41AYPCh. 23.5 - Prob. 42AYPCh. 23.5 - Describe the four factors that affect the...Ch. 23.5 - Does O2 or CO2 diffuse more easily through the...Ch. 23.5 - What effect do alveolar ventilation and Pulmonary...Ch. 23.5 - What are the anatomical shunt and the...Ch. 23.5 - Prob. 47AYPCh. 23.6 - Describe the partial pressure of O2 and CO2 in the...Ch. 23.6 - How do these pressures account for the movement of...Ch. 23.6 - Prob. 50AYPCh. 23.6 - Prob. 51AYPCh. 23.6 - What is the Bohr effect? How is it related to...Ch. 23.6 - Prob. 53AYPCh. 23.6 - Prob. 54AYPCh. 23.6 - Prob. 55AYPCh. 23.6 - Prob. 56AYPCh. 23.6 - Prob. 57AYPCh. 23.6 - Prob. 58AYPCh. 23.6 - Prob. 59AYPCh. 23.6 - Prob. 60AYPCh. 23.6 - Prob. 61AYPCh. 23.7 - Prob. 62AYPCh. 23.7 - Prob. 63AYPCh. 23.7 - Prob. 64AYPCh. 23.7 - Prob. 65AYPCh. 23.7 - Prob. 66AYPCh. 23.7 - Prob. 67AYPCh. 23.7 - Prob. 68AYPCh. 23.7 - Prob. 69AYPCh. 23.7 - Prob. 70AYPCh. 23.8 - Prob. 71AYPCh. 23.9 - Why do vital capacity, alveolar ventilation, and...Ch. 23.9 - Prob. 73AYPCh. 23 - The nasal cavity a. has openings, the paranasal...Ch. 23 - The larynx connects the oropharynx to the trachea....Ch. 23 - Terminal bronchioles branch to form a. the...Ch. 23 - Prob. 4RACCh. 23 - During quiet expiration, the a. abdominal muscles...Ch. 23 - Prob. 6RACCh. 23 - Prob. 7RACCh. 23 - Prob. 8RACCh. 23 - Prob. 9RACCh. 23 - Prob. 10RACCh. 23 - Prob. 11RACCh. 23 - Prob. 12RACCh. 23 - Prob. 13RACCh. 23 - Prob. 14RACCh. 23 - Prob. 15RACCh. 23 - Prob. 16RACCh. 23 - Prob. 17RACCh. 23 - Prob. 18RACCh. 23 - Which of these parts of the brainstem is correctly...Ch. 23 - Prob. 20RACCh. 23 - Prob. 21RACCh. 23 - Prob. 1CTCh. 23 - Prob. 2CTCh. 23 - Prob. 3CTCh. 23 - One technique for artificial respiration is...Ch. 23 - Prob. 5CTCh. 23 - Prob. 6CTCh. 23 - Prob. 7CTCh. 23 - Prob. 8CTCh. 23 - Prob. 9CTCh. 23 - Prob. 10CTCh. 23 - Compliance of the lungs and thorax is the volume...
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