HUMAN ANATOMY W/ACCESS
6th Edition
ISBN: 9781260929539
Author: SALADIN
Publisher: MCG
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Textbook Question
Chapter 23, Problem 9WWWTS
Briefly explain why each of the following statements is false, or reword it to make it true.
9. The respiratory system begins its development by budding from the posterior side of the esophagus.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 23 Solutions
HUMAN ANATOMY W/ACCESS
Ch. 23.1 - Answer the following questions to test your...Ch. 23.1 - Prob. 2BYGOCh. 23.1 - Prob. 3BYGOCh. 23.2 - Answer the following questions to test your...Ch. 23.2 - Prob. 5BYGOCh. 23.2 - Prob. 6BYGOCh. 23.2 - Prob. 7BYGOCh. 23.2 - Prob. 8BYGOCh. 23.3 - Prob. 1AWYKCh. 23.3 - Prob. 9BYGO
Ch. 23.3 - Prob. 10BYGOCh. 23.3 - Prob. 11BYGOCh. 23.4 - Prob. 1AWYKCh. 23.4 - Prob. 12BYGOCh. 23.4 - Prob. 13BYGOCh. 23.4 - Answer the following questions to test your...Ch. 23.4 - Prob. 15BYGOCh. 23.4 - Prob. 16BYGOCh. 23.5 - In a certain criminal investigation, the...Ch. 23.5 - Prob. 17BYGOCh. 23.5 - Prob. 18BYGOCh. 23.5 - Prob. 19BYGOCh. 23.5 - Answer the following questions to test your...Ch. 23.5 - Prob. 21BYGOCh. 23 - To test your knowledge, discuss the following...Ch. 23 - To test your knowledge, discuss the following...Ch. 23 - Prob. 23.1.3AYLOCh. 23 - Prob. 23.1.4AYLOCh. 23 - Prob. 23.2.1AYLOCh. 23 - Prob. 23.2.2AYLOCh. 23 - Prob. 23.2.3AYLOCh. 23 - Prob. 23.2.4AYLOCh. 23 - Prob. 23.2.5AYLOCh. 23 - Prob. 23.2.6AYLOCh. 23 - Prob. 23.2.7AYLOCh. 23 - To test your knowledge, discuss the following...Ch. 23 - Prob. 23.2.9AYLOCh. 23 - Prob. 23.2.10AYLOCh. 23 - To test your knowledge, discuss the following...Ch. 23 - Prob. 23.2.12AYLOCh. 23 - To test your knowledge, discuss the following...Ch. 23 - Prob. 23.3.2AYLOCh. 23 - To test your knowledge, discuss the following...Ch. 23 - To test your knowledge, discuss the following...Ch. 23 - Prob. 23.3.5AYLOCh. 23 - Prob. 23.3.6AYLOCh. 23 - Prob. 23.3.7AYLOCh. 23 - To test your knowledge, discuss the following...Ch. 23 - Prob. 23.4.1AYLOCh. 23 - Prob. 23.4.2AYLOCh. 23 - Prob. 23.4.3AYLOCh. 23 - Prob. 23.4.4AYLOCh. 23 - Prob. 23.4.5AYLOCh. 23 - Prob. 23.5.1AYLOCh. 23 - To test your knowledge, discuss the following...Ch. 23 - To test your knowledge, discuss the following...Ch. 23 - Prob. 23.5.4AYLOCh. 23 - Prob. 23.5.5AYLOCh. 23 - To test your knowledge, discuss the following...Ch. 23 - Prob. 23.5.7AYLOCh. 23 - Prob. 1TYRCh. 23 - The intrinsic laryngeal muscles regulate speech by...Ch. 23 - Prob. 3TYRCh. 23 - Prob. 4TYRCh. 23 - A deficiency of pulmonary surfactant is most...Ch. 23 - Prob. 6TYRCh. 23 - Which of the following are fewest in number but...Ch. 23 - Prob. 8TYRCh. 23 - Prob. 9TYRCh. 23 - Prob. 10TYRCh. 23 - Prob. 11TYRCh. 23 - Prob. 12TYRCh. 23 - Prob. 13TYRCh. 23 - Prob. 14TYRCh. 23 - Prob. 15TYRCh. 23 - Prob. 16TYRCh. 23 - Prob. 17TYRCh. 23 - Prob. 18TYRCh. 23 - Prob. 19TYRCh. 23 - Prob. 20TYRCh. 23 - Prob. 1BYMVCh. 23 - Prob. 2BYMVCh. 23 - Prob. 3BYMVCh. 23 - Prob. 4BYMVCh. 23 - Prob. 5BYMVCh. 23 - Prob. 6BYMVCh. 23 - Prob. 7BYMVCh. 23 - Prob. 8BYMVCh. 23 - Prob. 9BYMVCh. 23 - Prob. 10BYMVCh. 23 - Prob. 1WWWTSCh. 23 - Prob. 2WWWTSCh. 23 - Prob. 3WWWTSCh. 23 - Prob. 4WWWTSCh. 23 - Prob. 5WWWTSCh. 23 - Briefly explain why each of the following...Ch. 23 - Briefly explain why each of the following...Ch. 23 - Briefly explain why each of the following...Ch. 23 - Briefly explain why each of the following...Ch. 23 - Briefly explain why each of the following...Ch. 23 - Discuss how the different functions of the...Ch. 23 - From the upper to the lower end of the trachea,...Ch. 23 - The bronchioles are to the airway and airflow what...Ch. 23 - Prob. 4TYCCh. 23 - Prob. 5TYC
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