The hypothesis that can account for the inhibition of ATP-dependent citrate lyase by hydroxycitric acid has to be determined. Also, and the impact of fatty acid synthesis on this inhibition has to be determined. Concept Introduction: Certain inhibitors may compete to bind at the active site of the enzyme as they resemble the structure of the natural substrate of that particular enzyme. This is known as competitive inhibition. They may occupy the active site for a transient period of time as they are held by only weak forces and thus dissociate quickly unlike the case of irreversible inhibition where usually strong covalent interaction does not allow the inhibitor to dissociate from the active site.

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Chapter 23, Problem 4MCP

Interpretation Introduction

Interpretation:

The hypothesis that can account for the inhibition of ATP-dependent citrate lyase by hydroxycitric acid has to be determined. Also, and the impact of fatty acid synthesis on this inhibition has to be determined.

Concept Introduction:

Certain inhibitors may compete to bind at the active site of the enzyme as they resemble the structure of the natural substrate of that particular enzyme. This is known as competitive inhibition. They may occupy the active site for a transient period of time as they are held by only weak forces and thus dissociate quickly unlike the case of irreversible inhibition where usually strong covalent interaction does not allow the inhibitor to dissociate from the active site.

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