FUNDAMENTALS OF BIOCHEMISTRY-ACCESS
5th Edition
ISBN: 9781119498742
Author: Voet
Publisher: WILEY
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Chapter 23, Problem 27CQ
Summary Introduction
To explain: How the threonine catabolism helps meet the cells energy demands and their high rate of DNA synthesis.
Concept introduction: The cell has alternative mechanism to meet the energy and metabolites need. To meet the high demand of
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Pyruvate is accepted into the TCA cycle by a “feeder” reaction using the pyruvatedehydrogenase complex, resulting in acetyl-CoA and CO2. Provide a full mechanismfor this reaction utilizing the TPP cofactor. Include the roles of all cofactors.
B- Vitamins are converted readily into important metabolic cofactors. Deficiency inany one of them has serious side effects.
a. The disease beriberi results from a vitamin B 1 (Thiamine) deficiency and ischaracterized by cardiac and neurological symptoms. One key diagnostic forthis disease is an increased level of pyruvate and α-ketoglutarate in thebloodstream. How does this vitamin deficiency lead to increased serumlevels of these factors?
b. What would you expect the effect on the TCA intermediates for a patientsuffering from vitamin B 5 deficiency?
c. What would you expect the effect on the TCA intermediates for a patientsuffering from vitamin B 2 /B 3 deficiency?
Draw the Krebs Cycle and show the entry points for the amino acids Alanine,Glutamic Acid, Asparagine, and Valine into the Krebs Cycle - (Draw the Mechanism).
How many rounds of Krebs will be required to waste all Carbons of Glutamic Acidas CO2?
Chapter 23 Solutions
FUNDAMENTALS OF BIOCHEMISTRY-ACCESS
Ch. 23 - Prob. 1ECh. 23 - Prob. 2ECh. 23 - Prob. 3ECh. 23 - 4. When starved, bacteria produce the...Ch. 23 - Prob. 5ECh. 23 - Prob. 6ECh. 23 - 7. Calculate the cost, in ATP equivalents, of...Ch. 23 - Prob. 8ECh. 23 - Prob. 9ECh. 23 - Prob. 10E
Ch. 23 - Prob. 11ECh. 23 - Prob. 12ECh. 23 - Prob. 13ECh. 23 - Prob. 14ECh. 23 - Prob. 15ECh. 23 - Prob. 16ECh. 23 - Prob. 17ECh. 23 - Prob. 18ECh. 23 - Prob. 19ECh. 23 - Prob. 20ECh. 23 - Prob. 22ECh. 23 - Prob. 21ECh. 23 - Prob. 23ECh. 23 - Prob. 24ECh. 23 - Prob. 25CQCh. 23 - Prob. 26CQCh. 23 - Prob. 27CQCh. 23 - Prob. 28CQCh. 23 - Prob. 29CQCh. 23 - Prob. 30CQCh. 23 - 31. Why is gout more prevalent in populations that...Ch. 23 - Prob. 32CQCh. 23 - Prob. 33CQCh. 23 - Prob. 34CQCh. 23 - Prob. 1MTE
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