Concept explainers
Interpretation:
If the deficiency of DAM (deoxyadenosine) methylase will decrease, increase or will have no effect on the mutation rates should be explained.
Concept introduction:
Deoxyadenosine methylase is commonly referred to as DAM methylase. This is an enzyme that catalyzes the addition of methyl (
Explanation of Solution
The process of addition of methyl group to the adenine of the sequence of
During the process of replication, methylated DNA strand remains temporarily unmethylated. Thus, in the two strands of DNA, one strand of DNA remains methylated, while the other strand of DNA remains unmethylated. This situation is referred to as hem-methylation. The unmethylated strand of DNA quickly methylates in the presence of enzyme dam methylase.
In the deficiency of enzyme dam methylase, DNA is left completely unmethylated. Also, the unmethylated DNA has more probability to undergo mutation. Thus, the deficiency of dam methylase enzyme increases the spontaneous mutation rates.
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Chapter 23 Solutions
Biochemistry: Concepts and Connections (2nd Edition)
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