To describe:
The way in which the human papillomavirus (HPV), which is associated with warts, causes cervical cancer.
Concept introduction:
Apart from warts, four strains of human papillomavirus (HPV) also cause cervical cancer in women. “Gardasil” vaccine provides protection against all four of these strains, and the vaccine “Cervarix” protects against two of these strains.
In 2013, it was reported that the cervical cancer cases have reduced by 56% after the introduction of vaccines. It is recommended that all women between the ages of 14-26 years old should get vaccinated against HPV.
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Explanation of Solution
Even though the human papillomavirus (HPV) is mainly associated with warts, it is also responsible for causing cervical cancer in women. When a woman has been exposed to a prolonged infection by HPV, there’s a risk that she would develop cervical cancer. This type of cancer proceeds gradually without showing any symptoms or signs, causing harm along the way. It can only be diagnosed by Papanicolaou (Pap) smear, which involves examining of cells that have been extracted from the infected cervix for abnormalities.
Human papillomavirus (HPV) causes cervical cancer in women who have been exposed to HPV infections for a significantly long period of time. This type of cancer occurs without showing any signs or symptoms and gradually causes harm.
To describe:
The reason for which young women and preteens should receive the HPV vaccines.
Concept introduction:
It has been reported that the cervical cancer cases have reduced by 56% after the introduction of vaccines like Gardasil and Cervarix. It is recommended that all women between the ages of 14-26 years old should get vaccinated against HPV.
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Explanation of Solution
Young women and preteens should receive the HPV vaccines because this vaccine is a protective measure against cancers that are caused by prolonged infection by “human papillomavirus” (HPV). This virus is responsible for infecting teens and adults, and the infection might gradually develop into cancer without showing any symptoms. The virus can be transmitted from one person to other by sexual contact and so millions of HPV infection cases are reported every year.
Young men can also develop oropharyngeal cancer by HPV infection in the mouth due to performing oral sex with an infected partner.
Young women and preteens should receive the HPV vaccines because this as a preventive measure against prolonged infection by human papillomavirus (HPV) that might develop into cancer later in life. HPV infection can spread through sexual and oral intercourse with an infected person.
To describe:
The recommendations for males to receive the HPV vaccines.
Concept introduction:
The human papillomavirus (HPV) is responsible for infecting teens and adults, and the infection might gradually develop into cancer of the region that is exposed to the virus, without showing any symptoms. HPV infection can spread through sexual and oral intercourse with an infected person.
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Explanation of Solution
Even though oropharyngeal cancer is commonly caused by tobacco and alcohol use, there has been an increased number of cases involving oropharyngeal cancer caused by HPV infection in men. This HPV source or this type of cancer is transmitted through oral sex, which is a common practice among young individuals. Oropharyngeal cancer caused by HPV in males is the same as cervical cancer caused by HPV in females.
Therefore, for prevention against the infection and for limiting its exposure to females, young men and boys are also recommended to receive the HPV vaccine.
Young men and boys are also recommended to receive the HPV vaccine for prevention against the HPV infection and for limiting its exposure to females, as these infections can gradually develop into cancers.
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Chapter 23 Solutions
MICROBIOLOGY W/ACCESS
- P You are studying a population of 100 flowers that has two alleles at a locus for flower color, blue (B) and green (G). There are 15 individuals with the BB genotype, 70 individuals with the BG genotype, and 15 individuals with the GG genotype. (a) What are the allele frequencies of B and G in the starting population? Show your calculations. (2 pts) (b) Is this population in Hardy-Weinberg equilibrium? Show your calculations. (3 pts) 12pt v Paragraph BIU UA AV & VT2V f CO Varrow_forwardIn a natural population of outbreeding plants, the variance of the total number of seeds per plant is 16. From the natural population, 20 plants are taken into the laboratory and developed into separate true-breeding lines by self- fertilization-with selection for high, low, or medium number of seeds-for 10 generations. The average variance in the tenth generation in each of the 20 sets is about equal and averages 5.8 across all the sets. Estimate the broad-sense heritability for seed number in this population. (4 pts) 12pt v Paragraph BIUA V V T² v B ① O wordsarrow_forwardIn a natural population of outbreeding plants, the variance of the total number of seeds per plant is 16. From the natural population, 20 plants are taken into the laboratory and developed into separate true-breeding lines by self- fertilization-with selection for high, low, or medium number of seeds-for 10 generations. The average variance in the tenth generation in each of the 20 sets is about equal and averages 5.8 across all the sets. Estimate the broad-sense heritability for seed number in this population. (4 pts) 12pt v Paragraph BI DI T² v ✓ B°arrow_forward
- Question 1 In a population of Jackalopes (pictured below), horn length will vary between 0.5 and 2 feet, with the mean length somewhere around 1.05 feet. You pick Jackalopes that have horn lengths around 1.75 feet to breed as this appears to be the optimal length for battling other Jackalopes for food. After a round of breeding, you measure the offsprings' mean horn length is 1.67. What is the heritability of horns length (h2)? Is Jackalope horn length a heritable trait? (4 pts)? 12pt v Paragraph BIU A ✓arrow_forwardFrequency of allele A1 Question 2 The graph below shows results of two simulations, both depicting the rise in frequency of beneficial allele in a population of infinite size. The selection coefficient and the starting frequency are the same, but in one simulation the beneficial allele is dominant and in the other it is recessive. Neither allele is fixed by 500 generations. 1.0 1 0.8 0.6 0.4 2 0.2 0 0 100 200 300 400 500 Generation (a) Which simulation shows results for a dominant and which shows results for a recessive allele? How can you tell? (4 pts) (b) Neither of the alleles reaches fixation by 500 generations. If given enough time, will both of these alleles reach fixation in the population? Why or why not? (3 pts) 12pt Paragraph BIU AT2v Varrow_forwardQuestion 14 The relative fitnesses of three genotypes are WA/A= 1.0, WA/a = 0.7, and Wa/a = 0.3. If the population starts at the allele frequency p = 0.5, what is the value of p in the next generation? (3 pts) 12pt v V Paragraph B I U D V T² v V V p O words <arrow_forward
- According to a recent study, 1 out of 50,000 people will be diagnosed with cystic fibrosis. Cystic fibrosis can be caused by a mutant form of the CFTR gene (dominant gene symbol is F and mutant is f). A. Using the rate of incidence above, what is the frequency of carriers of the cystic fibrosis allele for CFTR in the US? (3 pts) B. In a clinical study, 400 people from the population mentioned in (A.) were genotyped for BRCA1 Listed below are the results. Are these results in Hardy- Weinberg equilibrium? Use Chi Square to show whether or not they are. (3 pts) BRCA1 genotype # of women 390 BB Bb bb 10 0 12pt Paragraph L BIUAV V T² v Varrow_forwardOutline a method for using apomixis to maintain feminized CannabisAssume apomixis is controlled by a single dominant gene. You can choose the type of apomixis: obligate or facultative, gametophytic or sporophytic. Discuss advantages and disadvantages of your proposed method.arrow_forwardKinetics: One-Compartment First-Order Absorption 1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration. Using this data and set of graphs, determine:(calculate for each variable) (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e)absolute ip bioavailability, Fip (f) absolute po bioavailability, Fpoarrow_forward
- 3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug: (a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate) (b) Estimate the time for maximum plasma concentration (tmax). (c) Estimate the maximum plasma concentration (Cmax). (d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.) (e)…arrow_forwardList substitutions in your diet you could make to improve it based on what you know now about a balanced diet. For instance, if you like to drink soda, you might substitute skim milk or water for some of the soft drinks you consumed. List the item you wish to replace with the new item and what you hope to accomplish with that substitution. Be sure to choose foods you know that you'd enjoy and you consider more "healthful." If you feel your diet is already balanced, describe how you accomplish your balanced intake and when you began eating this way.arrow_forwardWhich single food item contained you ate for the 3 days with the most sodium?arrow_forward
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