Biochemistry 410/411 Textbook - 5th Edition - Custom Texas A&M University
Biochemistry 410/411 Textbook - 5th Edition - Custom Texas A&M University
5th Edition
ISBN: 9781119302940
Author: Voet
Publisher: WILEY C
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Chapter 23, Problem 13E
Summary Introduction

To explain: The reason why methotrexate inhibits the synthesis of histidine and methionine.

Concept introduction: Competitive inhibition is the competition between a substrate and inhibitor that compete for the same active site of enzyme. The compound which resembles the substrate can act as competitive inhibitor.

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For a red blood cell (erythrocyte) undergoing active glycolysis, briefly explain how increases in concentration of the following factors are likely to affect glycolytic flux. a. ATP b. AMP c. F-1,6-BP d. F-2,6-BP e. Citrate f. Glucose-6-phosphate
The ∆G°’ for hydrolysis of phosphoenol pyruvate is -62.2 kJ/mol. The standard freeenergy of ATP hydrolysis is -30.5 kJ/mol. A. What is the standard free energy and K eq of the spontaneous reaction betweenADP/ATP and phosphoenol pyruvate. B. Repeat A for F-1,6-BP (∆G°’=-16.7 kJ/mol) and 1,3-BPG (∆G°’=-49.6 kJ/mol)hydrolysis. C. If the ATP and ADP concentrations are 8mM and 1mM respectively, what would bethe ratio of pyruvate/phosphoenolpyruvate at equilibrium?
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