BIOLOGY THE ESSENTIALS CONNECT ONLY
BIOLOGY THE ESSENTIALS CONNECT ONLY
3rd Edition
ISBN: 9781264735433
Author: Hoefnagels
Publisher: McGrawHill
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Chapter 23, Problem 11WIO
Summary Introduction

To determine:

The nonbiological examples of negative and positive feedback.

Introduction:

Feedback can be defined as a process by which output of a particular system is routed back as specific inputs as a part of cause-and-effect on the body. Two types of feedback mechanisms are present that can be categorized into positive feedback and negative feedback.

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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.  b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake? Options: A. Dose; Increase dose     B. Dose; Decrease dose     C. Dose; Do not change dose     D. Interval; Increase the interval between doses (give the drug less frequently)    E. Interval; Decrease the interval between doses (give the drug more frequently)     F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
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