ANATOMY+PHYSIOLOGY (LL) >CUSTOM PKG.<
4th Edition
ISBN: 9781264457861
Author: McKinley
Publisher: MCG CUSTOM
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Chapter 22.5, Problem 19WDYL
What would happen if a thymocyte that failed the negative selection test was not destroyed and instead entered the blood to circulate as a T-lymphocyte?
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At 5 months of age, Christina Kitchenman was admitted to the hospital with a fever and a severe non-productive cough that was subsequently determined by immunofluorescence staining to be pneumocystosis, a form of pneumonia caused by an opportunistic yeast-like fungus. Her CD4 T-cell count (220 μl –1) was much lower than expected, at only one-third of her CD8 T-cell count (650 μl –1). Her B-cell count was slightly higher than normal. An immunodeficiency was suspected, so T-lymphocyte functionality tests were carried out, proving that Christina’s T cells did not respond to a specific antigen stimulus involving tetanus toxoid as a recall antigen, even though she had received routine vaccination for tetanus (DPT vaccine) several months previously. Normal T-cell proliferation responses, however, were detected upon exposure of peripheral blood mononuclear cells to either the plant lectin mitogen phytohemagglutinin or to allogeneic B lymphocytes. Further tests revealed hypogammaglobulinemia,…
Chapter 22 Solutions
ANATOMY+PHYSIOLOGY (LL) >CUSTOM PKG.<
Ch. 22.1 - Which pathogen must enter a cell to replicate?...Ch. 22.2 - Prob. 2WDYLCh. 22.2 - What is the definition of a cytokine? How are...Ch. 22.2 - Prob. 4WDYLCh. 22.3 - Prob. 5WDYLCh. 22.3 - Prob. 6WDYLCh. 22.3 - Prob. 7WDYLCh. 22.3 - How do NK cells accomplish the task of eliminating...Ch. 22.3 - Prob. 9WDYLCh. 22.3 - Prob. 10WDYL
Ch. 22.3 - Prob. 11WDYLCh. 22.3 - Prob. 12WDYLCh. 22.4 - Prob. 13WDYLCh. 22.4 - What distinguishes a hapten from an antigen?Ch. 22.4 - Prob. 15WDYLCh. 22.4 - Which type of MHC class molecules is found on all...Ch. 22.4 - Prob. 17WDYLCh. 22.5 - Prob. 18WDYLCh. 22.5 - What would happen if a thymocyte that failed the...Ch. 22.5 - Prob. 20WDYLCh. 22.6 - Prob. 21WDYLCh. 22.6 - How do cytokines released by helper T-lymphocytes...Ch. 22.6 - Prob. 23WDYLCh. 22.6 - Prob. 24WDYLCh. 22.6 - Prob. 25WDYLCh. 22.7 - Prob. 26WDYLCh. 22.7 - Prob. 27WDYLCh. 22.7 - Prob. 28WDYLCh. 22.8 - Prob. 29WDYLCh. 22.8 - What are the six major functions of antibodies?...Ch. 22.8 - Which subclass of antibodies is most prevalent?...Ch. 22.9 - Prob. 32WDYLCh. 22.9 - Prob. 33WDYLCh. 22.9 - Prob. 34WDYLCh. 22 - _____ 1. All of the following are phagocytic cells...Ch. 22 - _____ 2. This cell releases cytokines to activate...Ch. 22 - _____ 3. This cell is activated by binding...Ch. 22 - _____ 4. These two cells destroy an infected cell...Ch. 22 - _____ 5. All of the following are functions of...Ch. 22 - _____ 6. The four characteristics of adaptive...Ch. 22 - _____ 7. During which process does additional...Ch. 22 - _____ 8. This chemical is released by...Ch. 22 - _____ 9. The correct sequence of the major events...Ch. 22 - Prob. 10DYKBCh. 22 - Compare the general characteristics of innate...Ch. 22 - Define the inflammatory response, and explain its...Ch. 22 - Describe an antigen.Ch. 22 - Describe class I and class II MHC molecules, and...Ch. 22 - Prob. 15DYKBCh. 22 - Prob. 16DYKBCh. 22 - Explain the general function of cytotoxic...Ch. 22 - Describe both the function of antibodies and...Ch. 22 - There are two branches of adaptive immunity:...Ch. 22 - Prob. 20DYKBCh. 22 - Prob. 1CALCh. 22 - Prob. 2CALCh. 22 - Prob. 3CALCh. 22 - Prob. 4CALCh. 22 - Prob. 5CALCh. 22 - Prob. 1CSLCh. 22 - Prob. 2CSLCh. 22 - Prob. 3CSL
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- You have a patient with abnormally high IgE antibodies. What are two scenarios that might lead to a high level of IgE antibodies? How would you find out which scenario is causing the increase in IgE?arrow_forwardYou are a nurse caring for a patient with a pulmonary (lung) mold infection, The mold represents a large, macroscopic pathogen. Which of the following adaptive immune system responses would be MOST effective at controlling the mold infection? O High levels of IgA that promote neutralization O High levels of IgG that promotes agglutination, complement activation, and opsonization An increase in host cell production of MHC I High levels of IgE that promote vascular change in association with mast cells O Production of a large population of antigen-specific Tc cells to destroy mold cellsarrow_forwardAccording to the clonal selection theory, all immunoglobulin molecules in an individual B cell have the same antigenic specificity. Explain why the presence of IgM and IgD on the same B cell does not violate the nonspecificity implied by clonal selection.arrow_forward
- Herd immunity means that the entire population (not just those who are vaccinated) are protected from a disease. What is one way that herd immunity protects an unvaccinated person (such as an infant who is too young to be vaccinated or a person who is immunocompromised)?arrow_forwardWhy is it important to monitor the T lymphocytes in someone with AIDS?arrow_forwardWhat is the enzymatic tag on the antibodies that interacts with the substrate causing the color change?arrow_forward
- Give the sequence of events from the time the B-cell encounters the antigen to actual antibody production.arrow_forwardGenerally, polysaccharides are not good antigens, because B cells that recognize them cannot get T-cell help. But for some pathogens, such as Streptococcus pneumoniae opsonization by antibodies that bind the thick polysaccharide "capsule" layer surrounding the bacteria is the major mechanism of clearing the infection. As expected, a pure polysaccharide vaccine is not terribly effective, but much better immunity is achieved by vaccinating with a polysaccharide covalently linked "conjugated" to an unrelated protein. Explain how this conjugate vaccine allows B cells capable of making anti-polysaccharide antibodies.arrow_forward(56) A 1 year old boy dies of staphylococcal pneumonia. He has had multiple skin infections since birth. Separation of the umbilical cord was delayed. A skin window test was performed and no leukocyte accumulated on the cover ship. The cytometric analysis showed that only 5% of the T lymphocytes reacted with a monoclonal antibody to leukocyte functional antigen-1 chain (CD 18) compared with reactivity of 62 % for a normal subject. Just prior to death, his leukocyte count was 75,000/mm3. Which of the following is the most likely diagnosis? (A) AIDS (B) Cogenital Asplenia (C)Leukocyte Adhesion Deficiency (D) Severe Combined Immunodeficiency Disease (E) X linked agammaglobulinemiaarrow_forward
- Heidelberger observed that complement inhibited the formation of precipitating antigen-antibody lattices. Therefore, what factors influence the immune complex lattice size?arrow_forwardConstruct a typical antibody (immunoglobulin) molecule. Label the variable and constant regions, and the light and heavy chains. Indicate which region determines the antibody’s isotype (class). Indicate which region determines its antigenic specificity.arrow_forwardMany cells in the human body have proteins on the surface that are able to interact with the receptors of helper T cells. Explain the mechanisms and why it is that such an interaction or signal does not usually result in an autoimmune reaction?arrow_forward
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