ANATOMY PHYS VOL II W ACCESS CUSTOM
9th Edition
ISBN: 9781264412303
Author: SALADIN
Publisher: MCG CUSTOM
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Chapter 22.2, Problem 9BYGO
Summary Introduction
Introduction:
Respiration is a normal phenomenon and occurs when the contraction and relaxation of the muscles surrounding the lungs occurs as air enters and leaves the lungs. The contraction and relaxation of the lungs are brought about by the muscles surrounding the lungs. Some of the muscles that help in respiration are abdominal muscles, intercostal muscles, and the diaphragm. The Boyle's law states that for a constant amount of an ideal gas kept at a constant temperature, the pressure of the gas is inversely proportional to the volume.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 22 Solutions
ANATOMY PHYS VOL II W ACCESS CUSTOM
Ch. 22.1 - A dust particle is inhaled and gets into an...Ch. 22.1 - Prob. 2BYGOCh. 22.1 - Prob. 3BYGOCh. 22.1 - Prob. 4BYGOCh. 22.1 - Prob. 5BYGOCh. 22.1 - Prob. 6BYGOCh. 22.1 - Prob. 1AYLOCh. 22.1 - Prob. 2AYLOCh. 22.1 - Prob. 3AYLOCh. 22.1 - Prob. 4AYLO
Ch. 22.1 - Prob. 5AYLOCh. 22.1 - Prob. 6AYLOCh. 22.1 - Prob. 7AYLOCh. 22.1 - Gross anatomy of the lungs; how the right and left...Ch. 22.1 - Prob. 9AYLOCh. 22.1 - How bronchioles differ from bronchi; two types of...Ch. 22.1 - Prob. 11AYLOCh. 22.1 - Prob. 12AYLOCh. 22.2 - Prob. 7BYGOCh. 22.2 - Prob. 8BYGOCh. 22.2 - Prob. 9BYGOCh. 22.2 - Prob. 10BYGOCh. 22.2 - Prob. 11BYGOCh. 22.2 - Suppose a healthy person has a tidal volume of 650...Ch. 22.2 - Prob. 13BYGOCh. 22.2 - Prob. 1AYLOCh. 22.2 - Prob. 2AYLOCh. 22.2 - Prob. 3AYLOCh. 22.2 - Locations and roles of the central and peripheral...Ch. 22.2 - Prob. 5AYLOCh. 22.2 - Prob. 6AYLOCh. 22.2 - Prob. 7AYLOCh. 22.2 - Prob. 8AYLOCh. 22.2 - Prob. 9AYLOCh. 22.2 - Prob. 10AYLOCh. 22.2 - Prob. 11AYLOCh. 22.2 - Prob. 12AYLOCh. 22.2 - Use of the spirometer to measure pulmonary...Ch. 22.2 - Prob. 14AYLOCh. 22.2 - Prob. 15AYLOCh. 22.2 - Prob. 16AYLOCh. 22.3 - Why is the composition of alveolar air different...Ch. 22.3 - Prob. 15BYGOCh. 22.3 - Prob. 16BYGOCh. 22.3 - Prob. 17BYGOCh. 22.3 - Prob. 18BYGOCh. 22.3 - Prob. 19BYGOCh. 22.3 - Prob. 20BYGOCh. 22.3 - Prob. 21BYGOCh. 22.3 - Prob. 22BYGOCh. 22.3 - Composition of the atmosphere and average partial...Ch. 22.3 - Prob. 2AYLOCh. 22.3 - Prob. 3AYLOCh. 22.3 - Prob. 4AYLOCh. 22.3 - Prob. 5AYLOCh. 22.3 - Prob. 6AYLOCh. 22.3 - Prob. 7AYLOCh. 22.3 - Prob. 8AYLOCh. 22.3 - Prob. 9AYLOCh. 22.3 - Prob. 10AYLOCh. 22.3 - Prob. 11AYLOCh. 22.3 - Prob. 12AYLOCh. 22.3 - Prob. 13AYLOCh. 22.3 - Prob. 14AYLOCh. 22.3 - Prob. 15AYLOCh. 22.3 - Prob. 16AYLOCh. 22.4 - Prob. 23BYGOCh. 22.4 - Prob. 24BYGOCh. 22.4 - Prob. 25BYGOCh. 22.4 - The definition of hypoxia; its four varieties and...Ch. 22.4 - Prob. 2AYLOCh. 22.4 - Prob. 3AYLOCh. 22.4 - The most common cause of lung cancer, and the...Ch. 22 - The nasal cavity is divided by the nasal septum...Ch. 22 - The intrinsic laryngeal muscles regulate speech by...Ch. 22 - The latest air passages that engage in gas...Ch. 22 - Prob. 4TYRCh. 22 - Prob. 5TYRCh. 22 - Prob. 6TYRCh. 22 - According to_______ the warming of air as it is...Ch. 22 - Prob. 8TYRCh. 22 - Prob. 9TYRCh. 22 - Prob. 10TYRCh. 22 - Prob. 11TYRCh. 22 - Within each lung, the airway forms a branching...Ch. 22 - Prob. 13TYRCh. 22 - Prob. 14TYRCh. 22 - Prob. 15TYRCh. 22 - Some inhaled air does not participate in gas...Ch. 22 - Prob. 17TYRCh. 22 - Prob. 18TYRCh. 22 - The matching of airflow to blood flow in any...Ch. 22 - Prob. 20TYRCh. 22 - Prob. 1BYMVCh. 22 - Prob. 2BYMVCh. 22 - Prob. 3BYMVCh. 22 - Prob. 4BYMVCh. 22 - eu-Ch. 22 - meterCh. 22 - Prob. 7BYMVCh. 22 - Prob. 8BYMVCh. 22 - Prob. 9BYMVCh. 22 - Prob. 10BYMVCh. 22 - Prob. 1WWTSCh. 22 - Prob. 2WWTSCh. 22 - Prob. 3WWTSCh. 22 - Prob. 4WWTSCh. 22 - Prob. 5WWTSCh. 22 - Prob. 6WWTSCh. 22 - Prob. 7WWTSCh. 22 - Prob. 8WWTSCh. 22 - Prob. 9WWTSCh. 22 - Prob. 10WWTSCh. 22 - Prob. 1TYCCh. 22 - State whether hyperventilation would raise or...Ch. 22 - Prob. 3TYCCh. 22 - Consider a man in good health with a 650 mL tidal...Ch. 22 - Prob. 5TYC
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