Laboratory Manual For Human Anatomy & Physiology
4th Edition
ISBN: 9781260159080
Author: Martin, Terry R., Prentice-craver, Cynthia
Publisher: Mcgraw-hill Education,
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Textbook Question
Chapter 22, Problem 7PL
Pre-Lab Questions Select the correct answer for each of the following questions:
Which of the following muscles is the most visible from an anterior view of a person in anatomical position?
a. splenius capitis
b. nasalis
c. temporalis
d. medial pterygoid
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 22 Solutions
Laboratory Manual For Human Anatomy & Physiology
Ch. 22 - Pre-Lab Questions Select the correct answer for...Ch. 22 - Pre-Lab Questions Select the correct answer for...Ch. 22 - Pre-Lab Questions Select the correct answer for...Ch. 22 - Pre-Lab Questions Select the correct answer for...Ch. 22 - Pre-Lab Questions Select the correct answer for...Ch. 22 - Pre-Lab Questions Select the correct answer for...Ch. 22 - Pre-Lab Questions Select the correct answer for...Ch. 22 - Pre-Lab Questions Select the correct answer for...Ch. 22 - Identity the muscles indicated in the head and...Ch. 22 - Identity the muscles indicated in the head and...
Ch. 22 - Complete the following statements: When the...Ch. 22 - Complete the following statements: The...Ch. 22 - Complete the following statements: The...Ch. 22 - Complete the following statements: The temporalis...Ch. 22 - Complete the following statements: The...Ch. 22 - Complete the following statements: The...Ch. 22 - Complete the following statements: The...Ch. 22 - Complete the following statements: The...Ch. 22 - Complete the following statements: The...Ch. 22 - Complete the following statements: The muscle used...Ch. 22 - Complete the following statements: The muscle used...Ch. 22 - Complete the following statements: The muscle used...Ch. 22 - Complete the following statements: The...Ch. 22 - Complete the following statements: The splenius...Ch. 22 - Name the muscle indicated by the following...Ch. 22 - Name the muscle indicated by the following...Ch. 22 - Name the muscle indicated by the following...Ch. 22 - Name the muscle indicated by the following...Ch. 22 - Name the muscle indicated by the following...Ch. 22 - Name the muscle indicated by the following...Ch. 22 - Name the muscle indicated by the following...Ch. 22 - Name the muscle indicated by the following...Ch. 22 - Name the muscle indicated by the following...Ch. 22 - Name the muscle indicated by the following...Ch. 22 - Name the muscle indicated by the following...Ch. 22 - Name the muscle indicated by the following...Ch. 22 - Name the muscle indicated by the following...Ch. 22 - Identify the muscles of various facial expressions...Ch. 22 - Identify the muscles of various facial expressions...Ch. 22 - Identify the muscles of various facial expressions...Ch. 22 - Identify the muscles of various facial expressions...Ch. 22 - Identify the muscles of various facial expressions...
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