The missing reagents have to be filled from the knowledge of the conversion of starting materials into the products. Concept Introduction : Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines . Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines. Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines. The reagents such as methyl iodide and silver oxide are given and used as the reaction conditions in the given reactions. This reaction is called Hofmann elimination. The amines undergo exhaustive alkylation in the presence of excess methyl iodide producing quaternary ammonium salt which is a excellent leaving group. After treatment with strong base, aqueous silver oxide and heat, quaternary ammonium salt gives alkenes . Alkene formation involves in E2 elimination. Through E2 elimination, the major product is less substituted alkene with trace amount of more substituted alkene. Alkenes on treatment with ozone followed by DMS give aldehydes . To find: The missing reagents in the given set of reactions Find the reagents involved in the reaction (a)

Question

Protecting Groups and Carbonyls 6) The synthesis generates allethrolone that exhibits high insect toxicity but low mammalian toxicity. They are used in pet shampoo, human lice shampoo, and industrial sprays for insects and mosquitos. Propose detailed mechanistic steps to generate the allethrolone label the different types of reagents (Grignard, acid/base protonation, acid/base deprotonation, reduction, oxidation, witting, aldol condensation, Robinson annulation, etc.) III + VI HS HS H+ CH,CH,Li III I II IV CI + P(Ph)3 V ༼ Hint: no strong base added VI S VII IX HO VIII -MgBr HgCl2,HgO HO. isomerization aqeuous solution H,SO, ༽༽༤༽༽ X MeOH Hint: enhances selectivity for reaction at the S X ☑

Answer 1

Question

Chapter 22, Problem 58PP

Interpretation Introduction

Interpretation: The missing reagents have to be filled from the knowledge of the conversion of starting materials into the products.

Concept Introduction:

Sodium cyanoborohydride is a strong reducing agent than sodium borohydride. It reduces the carbonyl group into amine group in a rapid way. So, it is called as reductive amination reactions. Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

Aldehyde or ketone group is reacted with primary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce secondary amines.

Aldehyde or ketone group is reacted with secondary amine in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce tertiary amines.

The reagents such as methyl iodide and silver oxide are given and used as the reaction conditions in the given reactions. This reaction is called Hofmann elimination. The amines undergo exhaustive alkylation in the presence of excess methyl iodide producing quaternary ammonium salt which is a excellent leaving group. After treatment with strong base, aqueous silver oxide and heat, quaternary ammonium salt gives alkenes. Alkene formation involves in E2 elimination. Through E2 elimination, the major product is less substituted alkene with trace amount of more substituted alkene.

Alkenes on treatment with ozone followed by DMS give aldehydes.

To find: The missing reagents in the given set of reactions

Find the reagents involved in the reaction (a)

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