ORGANIC CHEMISTRY-ACCESS
ORGANIC CHEMISTRY-ACCESS
6th Edition
ISBN: 9781260475586
Author: SMITH
Publisher: MCG
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Chapter 22, Problem 45P

β Vetivone is isolated from vetiver, a perennial grass that yields a variety of compounds used in traditional eastern medicine, pest control, and fragrance. In one synthesis, ketone A is converted to β vetivone by a two-step process: Michael reaction, followed by intramolecular aldol reaction. (a) What Michael acceptor is needed for the conjugate addition? (See problem 23.61 for another method to form the bicyclic ring system of β vetivone) (b) Draw a stepwise mechanism for the aldol reaction, which forms six-membered ring.

Chapter 22, Problem 45P, 24.44 Vetivone is isolated from vetiver, a perennial grass that yields a variety of compounds used

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