ANATOMY AND PHYSIOLOGY
17th Edition
ISBN: 9781630180928
Author: OpenStax
Publisher: OPENSTAX C
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Chapter 22, Problem 39CTQ
Compare and contrast the right and left lungs.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 22 Solutions
ANATOMY AND PHYSIOLOGY
Ch. 22 - Visit this site...Ch. 22 - Watch this video...Ch. 22 - Watch this video...Ch. 22 - Which of the following anatomical structures is...Ch. 22 - What is the function of the conchae in the nasal...Ch. 22 - The fauces connects which of the following...Ch. 22 - Which of the following are structural features of...Ch. 22 - Which of the following structures is not part of...Ch. 22 - What is the role of alveolar macrophages? to...Ch. 22 - Which of the following structures separates the...
Ch. 22 - A section of the lung that receives its own...Ch. 22 - The ________ circulation picks up oxygen for...Ch. 22 - The pleura that surrounds the lungs consists of...Ch. 22 - Which of the following processes does atmospheric...Ch. 22 - A decrease in volume leads to a(n) ________...Ch. 22 - The pressure difference between the intra-alveolar...Ch. 22 - Gas flow decreases as ________ increases....Ch. 22 - Contraction of the external intercostal muscles...Ch. 22 - Which of the following prevents the alveoli from...Ch. 22 - Gas moves from an area of ________ partial...Ch. 22 - When ventilation is not sufficient, which of the...Ch. 22 - Gas exchange that occurs at the level of the...Ch. 22 - The partial pressure of carbon dioxide is 45 mm Hg...Ch. 22 - Oxyhemoglobin forms by a chemical reaction between...Ch. 22 - Which of the following factors play a role in the...Ch. 22 - Which of the following occurs during the chloride...Ch. 22 - A low partial pressure of oxygen promotes...Ch. 22 - Increased ventilation that results in an increase...Ch. 22 - Exercise can trigger symptoms of AMS due to which...Ch. 22 - Which of the following stimulates the production...Ch. 22 - The olfactory pits form from which of the...Ch. 22 - A full complement of mature alveoli are present by...Ch. 22 - If a baby is bom prematurely before type II cells...Ch. 22 - When do fetal breathing movements begin? around...Ch. 22 - What happens to the fluid that remains in the...Ch. 22 - Describe the three regions of the pharynx and...Ch. 22 - If a person sustains an injury to the epiglottis,...Ch. 22 - Compare and contrast the conducting and...Ch. 22 - Compare and contrast the right and left lungs.Ch. 22 - Why are the pleurae not damaged during normal...Ch. 22 - Describe what is meant by the term lung...Ch. 22 - Outline the steps involved in quiet breathing.Ch. 22 - What is respiratory rate and how is it controlled?Ch. 22 - Compare and contrast Daltons law and Henrys law.Ch. 22 - A smoker develops damage to several alveoli that...Ch. 22 - Compare and contrast adult hemoglobin and fetal...Ch. 22 - Describe the relationship between the partial...Ch. 22 - Describe three ways in which carbon dioxide can be...Ch. 22 - Describe the neural factors involved in increasing...Ch. 22 - What is the major mechanism that results in...Ch. 22 - Dining what timeframe does a fetus have enough...Ch. 22 - Describe fetal breathing movements and their...
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